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. 2021 Oct;28(40):57192-57206.
doi: 10.1007/s11356-021-14530-0. Epub 2021 Jun 4.

Camellia japonica diminishes acetaminophen-induced acute liver failure by attenuating oxidative stress in mice

Weishun Tian  1 , Jing Zhao  1 , Byung-Kil Choo  2 , In-Shik Kim  1 , Dongchoon Ahn  1 , Hyun-Jin Tae  1 , Md Sadikul Islam  1 , Byung-Yong Park  3
Affiliations

Camellia japonica diminishes acetaminophen-induced acute liver failure by attenuating oxidative stress in mice

Weishun Tian et al. Environ Sci Pollut Res Int. 2021 Oct.

Abstract

This experiment was to explore the possible defensive properties and potential molecular mechanisms of Camellia japonica (CJ) against APAP-stimulated acute liver failure (ALF) in mice. In this study, we investigated the effects of CJ on APAP-induced hepatotoxicity. Mice were orally treated with CJ before or after challenge with APAP. Both pretreatment and post-treatment with CJ attenuated APAP-induced hepatotoxicity, as confirmed by significantly reduced serum toxicity biomarkers and improved hepatic pathological damage. Pretreatment with CJ drastically decreased the rise of hepatic inflammatory cytokines levels and weakened neutrophil infiltration. Furthermore, pretreatment with CJ dramatically decreased the levels of hepatic oxidative stress markers such as hepatic malondialdehyde (MDA) and 4-Hydroxynonenal (4-HNE) expression and rescued the reduced hepatic level of GSH caused by APAP overdose. Additionally, CJ pretreatment markedly attenuated cyclooxygenase-2 (COX-2) activation, transcription factor nuclear factor-kappa B (NF-κB) phosphorylation, c-Jun-N-terminal kinase (JNK) phosphorylation, and activated AMP-activated protein kinase (AMPK) signaling pathway in the liver. The present study thus reveals that CJ attenuated APAP-induced ALF by inhibiting COX-2 activation, NF-κB, and JNK phosphorylation and activating the AMPK signaling pathway.

Keywords: Acetaminophen; Acute liver failure; Camellia japonica; Hepatoprotective; Oxidative stress.

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