Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Oct;28(40):57216-57231.
doi: 10.1007/s11356-021-14319-1. Epub 2021 Jun 4.

Pesticide exposure and related health problems among farmworkers' children: a case-control study in southeast Iran

Danial Abdollahdokht  1   2 , Gholamreza Asadikaram  3   4   5 , Moslem Abolhassani  2   6 , Hossein Pourghadamyari  2 , Mojtaba Abbasi-Jorjandi  2   7 , Sanaz Faramarz  2 , Mohammad Hadi Nematollahi  8
Affiliations

Pesticide exposure and related health problems among farmworkers' children: a case-control study in southeast Iran

Danial Abdollahdokht et al. Environ Sci Pollut Res Int. 2021 Oct.

Abstract

Pesticides are potentially hazardous chemicals that can cause injury to human health and the environment. The purpose of this study was to evaluate organophosphate pesticides (OPPs) and organochlorine pesticides (OCPs) exposure in farmworkers' children aged 6 to 11 years in Jiroft city in southeastern Iran. One hundred twenty farmworkers' children as case and 53 non-farmworkers' children aged 6 to 11 years as control were selected and the serum levels of OCPs were measured by using gas chromatography in all participants. In addition, erythrocyte acetylcholinesterase (AChE) and arylesterase activity of paraoxonase-1 (PON-1) were measured to evaluate OPPs effects. Catalase (CAT), superoxide dismutase3 (SOD3), glutathione peroxidase (GPx3) activities, and the levels of serum malondialdehyde (MDA), total antioxidant capacity (TAC), nitric oxide (NO), and protein carbonyl (PC) were measured to investigate OCPs and OPPs effects on oxidative stress (OS). The serum levels of beta-HCH, 4,4 DDE, and 4,4 DDT in the case group were significantly higher than the control group. In addition, in the case group, AChE, PON-1, CAT, SOD3, and GPx3 activities and the levels TAC were significantly lower, while MDA, PC, and NO levels were significantly higher than the control group. OCPs as illegal pesticides are present in southeast Iran and children are exposed to OCPs and OPPs in the studied area. In addition, higher serum levels of pesticides may be a major contributor in OS development, as a cause of many diseases.

Keywords: Acetylcholinesterase; Farmworkers’ children; Organochlorine pesticides; Organophosphorus pesticides; Oxidative stress.

PubMed Disclaimer

References

    1. Abolhassani M, Asadikaram G, Paydar P, Fallah H, Aghaee-Afshar M, Moazed V, Akbari H, Moghaddam SD, Moradi A (2019) Organochlorine and organophosphorous pesticides may induce colorectal cancer; a case-control study. Ecotoxicol Environ Saf 178:168–177
    1. Ahmadi Z, Moradabadi A, Abdollahdokht D, Mehrabani M, Nematollahi MH (2019) Association of environmental exposure with hematological and oxidative stress alteration in gasoline station attendants. Environ Sci Pollut Res 26:20411–20417 - DOI
    1. Andersen HR, Schmidt IM, Grandjean P, Jensen TK, Budtz-Jørgensen E, Kjærstad MB, Bælum J, Nielsen JB, Skakkebæk NE, Main KM (2008) Impaired reproductive development in sons of women occupationally exposed to pesticides during pregnancy. Environ Health Perspect 116:566–572 - DOI
    1. Asadikaram G, Ram M, Izadi A, Sheikh Fathollahi M, Nematollahi MH, Najafipour H, Shahoozehi B, Mirhoseini M, Masoumi M, Shahrokhi N (2019) The study of the serum level of IL-4, TGF-β, IFN-γ, and IL-6 in overweight patients with and without diabetes mellitus and hypertension. J Cell Biochem 120:4147–4157 - DOI
    1. Benzie IF, Strain JJ (1996) The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal Biochem 239:70–76 - DOI

LinkOut - more resources