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. 2021 Jul;45(7):1504-1513.
doi: 10.1111/acer.14642.

Relationship between level of response to alcohol and acute tolerance

Robert M Anthenelli  1 , Benjamin S McKenna  1   2 , Tom L Smith  1 , Marc A Schuckit  1
Affiliations
Free article

Relationship between level of response to alcohol and acute tolerance

Robert M Anthenelli et al. Alcohol Clin Exp Res. 2021 Jul.
Free article

Abstract

Background: A low level of response (low LR) to alcohol correlates with the later development of alcohol-related problems. Although some of the underpinnings of LR are understood, little is known about the potential relationship between LR and acute tolerance. The current analyses tested the hypothesis that a low LR will be explained in part by more intense acute tolerance to alcohol during a drinking session.

Methods: Data were generated through a reanalysis of data from 120 individuals who were 18- to 25-year-old, sex-matched pairs of low and high LR drinkers who at baseline did not meet criteria for an alcohol use disorder. Each subject participated in an oral alcohol challenge in which they consumed about 0.7 ml ethanol per kg and acute tolerance was measured as the differences in alcohol's effects at similar breath alcohol levels (BrACs) during the rising and falling breath alcohol concentration (BrAC) curve. Measures included aspects of the Subjective High Assessment Scale (SHAS) and body sway.

Results: Contrary to our hypothesis, but similar to results with other alcohol measures, acute tolerance was significantly attenuated in low LR compared with high LR individuals on most SHAS scores. Neither LR group demonstrated acute tolerance to alcohol for sleepiness or body sway. Men and women did not differ on any of these measures.

Conclusion: These data do not support a role of acute tolerance in the low LR to alcohol as measured by subjective feelings of intoxication or body sway in these subjects, findings that were similar across males and females. In addition, consistent with the literature, the analyses demonstrated differences across measures such that acute tolerance was observed for most measures of subjective effects but not for body sway. Among the subjective effects, acute tolerance was observed for alcohol's intoxicating effect but not for feeling sleepy.

Keywords: Mellanby effect; acute tolerance; alcohol sensitivity; level of response; within-session tolerance.

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References

REFERENCES

    1. American Psychiatric Association (2013) Desk Reference to the Diagnostic Criteria From DSM-5. Arlington, VA: American Psychiatric Association.
    1. Baraona, E., Abittan, C.S., Dohmen, K., Moretti, M., Pozzato, G., Chayes, Z.W. et al. (2001) Gender differences in pharmacokinetics of alcohol. Alcoholism, Clinical and Experimental Research, 25, 502-507.
    1. Bucholz, K.K., Cadoret, R., Cloninger, C.R., Dinwiddie, S.H., Hesselbrock, V.M., Nurnberger, J.I. Jr et al. (1994) A new, semi-structured psychiatric interview for use in genetic linkage studies: A report on the reliability of the SSAGA. Journal of Studies on Alcohol, 55, 149-158.
    1. Comley, R.E. & Dry, M.J. (2020) Acute behavioral tolerance to alcohol. Experimental and Clinical Psychopharmacology, 28, 112-129.
    1. Conrod, P.J., O'Leary-Barrett, M., Newton, N., Topper, L., Castellanos-Ryan, N., Mackie, C. et al. (2013) Effectiveness of a selective, personality-targeted prevention program for adolescent alcohol use and misuse: A cluster randomized controlled trial. JAMA Psychiatry, 70, 334-342.

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