Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2021 Sep;12(9):1523-1525.
doi: 10.1111/jdi.13609. Epub 2021 Jul 19.

Challenges of optimizing insulin therapy for patients with type 2 diabetes mellitus

Fu-Shun Yen  1 , Chii-Min Hwu  2   3
Affiliations
Editorial

Challenges of optimizing insulin therapy for patients with type 2 diabetes mellitus

Fu-Shun Yen et al. J Diabetes Investig. 2021 Sep.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Survival probability estimated by the Kaplan–Meier method among insulin‐treated type 2 diabetes patients with different degrees of insulin persistence (adapted from Figure S1 in Yen et al.1). A total of 293,210 type 2 diabetes patients who had received insulin therapy were included in a retrospective cohort study based on Taiwan’s National Health Insurance Research Database. In Taiwan, a prescription is usually valid for 90 days. Accordingly, insulin persistence was defined as taking insulin continuously without stopping insulin for >90 days in the study. The degree of insulin persistence was reflected by the portion of time with continual treatment during a 2‐year observation period. Using the propensity score matching technique, mortality rates were compared between patients with or without 90% insulin persistence during the subsequent follow up. Patients with insulin persistence ≥90% were associated with a lower risk of all‐cause mortality than the groups with average or low insulin persistence (log‐rank test, P < 0.001).
See this image and copyright information in PMC

References

    1. Yen FS, Wei JC, Liu JS, et al. Persons with type 2 diabetes and high insulin persistence were associated with a lower risk of mortality: a nationwide retrospective cohort study. J Diabetes Investig 2021; 12: 146–154. - PMC - PubMed
    1. Jabbar A, Mohamed WMIBW, Ozaki R, et al. Patterns and trends in insulin initiation and intensification among patients with type 2 diabetes mellitus in the Western Pacific region. Curr Med Res Opin 2018; 34: 1653–1662. - PubMed
    1. Kalra S, Bajaj S, Sharma SK, et al. A practitioner's toolkit for insulin motivation in adults with type 1 and type 2 diabetes mellitus: evidence‐based recommendations from an international expert panel. Diabetes Ther 2020; 11: 585–606. - PMC - PubMed
    1. Khunti S, Khunti K, Seidu S. Therapeutic inertia in type 2 diabetes: prevalence, causes, consequences and methods to overcome inertia. Ther Adv Endocrinol Metab 2019; 10: 2042018819844694. 10.1177/2042018819844694. - DOI - PMC - PubMed
    1. Chan JCN, Gagliardino JJ, Ilkova H, et al. One in seven insulin‐treated patients in developing countries reported poor persistence with insulin therapy: real world evidence from the Cross‐Sectional International Diabetes Management Practices Study (IDMPS). Adv Ther 2021; 38: 3281–3298. 10.1007/s12325-021-01736-4. - DOI - PMC - PubMed

Publication types