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Comment
. 2021 Jun 3;28(6):985-987.
doi: 10.1016/j.stem.2021.05.010.

The treasure inside human naive pluripotency, generation of trophectoderm and blastoids

Riccardo De Santis  1 , Ali H Brivanlou  2
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The treasure inside human naive pluripotency, generation of trophectoderm and blastoids

Riccardo De Santis et al. Cell Stem Cell. .
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Abstract

Recent advances in human naive pluripotent stem cell culture have demonstrated their ability to generate trophectoderm and descendant trophoblast cell types. Moreover, the same cells when cultured in three-dimensional configurations self-organize to generate blastocyst-like structures called blastoids. These discoveries represent a major step forward in modeling early human embryonic development.

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Conflict of interest statement

Declaration of interests Ali H. Brivanlou is a co-founder of OvaNova Inc., as well as a co-founder of Rumi Scientific Inc. Riccardo De Santis declares no competing interests.

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