Pancreatic plasticity: Unlocking exocrine lineage specification
- PMID: 34087158
- DOI: 10.1016/j.stem.2021.05.006
Pancreatic plasticity: Unlocking exocrine lineage specification
Abstract
In this issue of Cell Stem Cell, Huang et al. (2021) and Breunig et al. (2021) developed human stem-cell-derived organoid culture systems to recapitulate pancreatic acinar and ductal lineages. This provides opportunities to study cellular plasticity and transformation in pancreatic cancer initiation and progression.
Copyright © 2021 Elsevier Inc. All rights reserved.
Comment on
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Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells.Cell Stem Cell. 2021 Jun 3;28(6):1105-1124.e19. doi: 10.1016/j.stem.2021.03.005. Epub 2021 Apr 28. Cell Stem Cell. 2021. PMID: 33915078 Free PMC article.
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Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.Cell Stem Cell. 2021 Jun 3;28(6):1090-1104.e6. doi: 10.1016/j.stem.2021.03.022. Epub 2021 Apr 28. Cell Stem Cell. 2021. PMID: 33915081 Free PMC article.
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