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Comment
. 2021 Jun 3;28(6):987-988.
doi: 10.1016/j.stem.2021.05.006.

Pancreatic plasticity: Unlocking exocrine lineage specification

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Pancreatic plasticity: Unlocking exocrine lineage specification

Jason R Pitarresi et al. Cell Stem Cell. .
Free article

Abstract

In this issue of Cell Stem Cell, Huang et al. (2021) and Breunig et al. (2021) developed human stem-cell-derived organoid culture systems to recapitulate pancreatic acinar and ductal lineages. This provides opportunities to study cellular plasticity and transformation in pancreatic cancer initiation and progression.

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