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. 2021 Jun 14;39(6):743-745.
doi: 10.1016/j.ccell.2021.05.003. Epub 2021 Jun 3.

Macrophage-tumor cell intertwine drives the transition into a mesenchymal-like cellular state of glioblastoma

Zhihong Chen  1 , Dolores Hambardzumyan  2
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Macrophage-tumor cell intertwine drives the transition into a mesenchymal-like cellular state of glioblastoma

Zhihong Chen et al. Cancer Cell. .
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Abstract

Macrophages are the major non-neoplastic infiltrates in the glioblastoma microenvironment. In this issue of Cancer Cell, Hara et al. (2021) demonstrate that macrophages induce a transition of glioblastoma cells into the mesenchymal-like cellular state associated with an increased mesenchymal program in macrophages themselves and enhanced cytotoxicity of T cells.

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