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doi: 10.1016/j.molcel.2021.05.019.
Intron removal by the spliceosome: A solo job or a team effort?
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- PMID: 34087179
- DOI: 10.1016/j.molcel.2021.05.019
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Intron removal by the spliceosome: A solo job or a team effort?
Mol Cell.
.
Free article
Abstract
Wan et al. (2021) establish a powerful new platform to measure the dynamics of transcription and splicing of endogenous genes in single cells in real time. Combining real-time measurements with multiple deep-sequencing tools reveals an unexpectedly high amount of spliceosome activity, prompting a reconsideration of current models of how introns are removed from pre-mRNA.
Copyright © 2021 Elsevier Inc. All rights reserved.
Comment on
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Dynamic imaging of nascent RNA reveals general principles of transcription dynamics and stochastic splice site selection.Cell. 2021 May 27;184(11):2878-2895.e20. doi: 10.1016/j.cell.2021.04.012. Epub 2021 May 11. Cell. 2021. PMID: 33979654 Free PMC article.
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