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1 Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address: Manuel.anderegg@dbmr.unibe.ch.
2 Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
3 Institute of Pathology, University of Bern, Bern, Switzerland.
1 Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address: Manuel.anderegg@dbmr.unibe.ch.
2 Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
3 Institute of Pathology, University of Bern, Bern, Switzerland.
(a–d) Histopathologic findings of patient 1 with (a,b) crescentic IgA nephritis and (c,d)…
Figure 1
(a–d) Histopathologic findings of patient 1 with (a,b) crescentic IgA nephritis and (c,d) mesangial IgA deposition on immunofluorescence and electron microscopy, and histopathologic findings of patient 2 with (e,f) severe necrotizing vasculitis, but (g,h) without deposition of Igs on immunofluorescence and electron microscopy. (a) Hematoxylin-eosin and silver staining (original magnification ×20). (b) Acid fuchsin–orange G stain (original magnification ×20). (c) Immunofluorescence against IgA (original magnification ×20). (d) Transmission electron microscopy. The arrowhead shows mesangial IgA depot. (e) Periodic acid–Schiff stain (original magnification ×20). (f) Acid fuchsin–orange G stain (original magnification ×20). (g) Immunofluorescence against IgA (original magnification ×20). (h) Transmission electron microscopy. Bar = 100 μm for light microscopy and immunofluorescence, and bar = 1 μm for electron microscopy. To optimize viewing of this image, please see the online version of this article at www.kidney-international.org.
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