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. 2021 Aug;100(2):474-476.
doi: 10.1016/j.kint.2021.05.016. Epub 2021 Jun 1.

De novo vasculitis after mRNA-1273 (Moderna) vaccination

Affiliations

De novo vasculitis after mRNA-1273 (Moderna) vaccination

Manuel A Anderegg et al. Kidney Int. 2021 Aug.
No abstract available

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Figures

Figure 1
Figure 1
(a–d) Histopathologic findings of patient 1 with (a,b) crescentic IgA nephritis and (c,d) mesangial IgA deposition on immunofluorescence and electron microscopy, and histopathologic findings of patient 2 with (e,f) severe necrotizing vasculitis, but (g,h) without deposition of Igs on immunofluorescence and electron microscopy. (a) Hematoxylin-eosin and silver staining (original magnification ×20). (b) Acid fuchsin–orange G stain (original magnification ×20). (c) Immunofluorescence against IgA (original magnification ×20). (d) Transmission electron microscopy. The arrowhead shows mesangial IgA depot. (e) Periodic acid–Schiff stain (original magnification ×20). (f) Acid fuchsin–orange G stain (original magnification ×20). (g) Immunofluorescence against IgA (original magnification ×20). (h) Transmission electron microscopy. Bar = 100 μm for light microscopy and immunofluorescence, and bar = 1 μm for electron microscopy. To optimize viewing of this image, please see the online version of this article at www.kidney-international.org.

References

    1. Baden L.R., El Sahly H.M., Essink B. Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine. N Engl J Med. 2021;384:403–416. - PMC - PubMed
    1. Suso A.S., Mon C., Onate Alonso I. IgA vasculitis with nephritis (Henoch-Schonlein purpura) in a COVID-19 patient. Kidney Int Rep. 2020;5:2074–2078. - PMC - PubMed
    1. Uppal N.N., Kello N., Shah H.H. De novo ANCA-associated vasculitis with glomerulonephritis in COVID-19. Kidney Int Rep. 2020;5:2079–2083. - PMC - PubMed
    1. Negrea L., Rovin B.H. Gross hematuria following vaccination for severe acute respiratory syndrome coronavirus 2 in 2 patients with IgA nephropathy. Kidney Int. 2021;99:1487. - PMC - PubMed
    1. Lebedev L., Sapojnikov M., Wechsler A. Minimal change disease following the Pfizer-BioNTech COVID-19 vaccine. Am J Kidney Dis. 2021;78:142–145. - PMC - PubMed