Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jul:152:110613.
doi: 10.1016/j.mehy.2021.110613. Epub 2021 May 26.

Does COVID 19 generate a milieu for propagation of mucormycosis?

Deepak Pandiar  1 , N Siva Kumar  2 , Rahul Anand  3 , Mala Kamboj  2 , Anjali Narwal  2 , P M Shameena  4
Affiliations

Does COVID 19 generate a milieu for propagation of mucormycosis?

Deepak Pandiar et al. Med Hypotheses. 2021 Jul.

Abstract

Corona Virus Disease 2019 (COVID 2019), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a dreadful infectious disease which has emerged as one of the most significant medical emergency affecting everyone directly or indirectly. COVID 2019 is a multisystem disease and causes severe immunosuppression. Initially thought to affect mainly the respiratory system, it strikes all vital organ systems and cause defects in cardio-circulatory, respiratory system and gastrointestinal systems to name a few leading to copious biochemical alterations. Reports show there is thromoembolism, raised ferritin levels, lymphocytopenia, thrombocytopenia, lactic acidosis, acute diabetes like state and cytokine storm. Data regarding levels of neutrophils is equivocal. Further there is increased incidence regarding high incidents of mucormycosis in COVID 2019 positive subjects. In the present paper, we identified and correlated the virus mediated biochemical alterations as the potential ideal environment for propagation of mucorales; and thus concentrate on early diagnosis and treatment of mucormycosis in COVID 2019 cases.

Keywords: ACE2; COVID 2019; Mucorales; Mucormycosis; SARS-CoV-2.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

References

    1. Terpos E., Ntanasis-Stathopoulos I., Elalamy I., Kastritis E., Sergentanis T.N., Politou M., et al. Hematological findings and complications of COVID-19. Am J Hematol. 2020;95:834–847. - PMC - PubMed
    1. Liu J., Li S., Liu J., Liang B., Wang X., Wang H., et al. Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients. EBioMedicine. 2020;55 - PMC - PubMed
    1. Parasher A. COVID-19: Current understanding of its pathophysiology, clinical presentation and treatment. Postgrad Med J. 2020 doi: 10.1136/postgradmedj-2020-138577. postgradmedj-2020-138577. Epub ahead of print. - DOI - PMC - PubMed
    1. Samanta J., Gupta R., Singh M.P., Patnaik I., Kumar A., Kochhar R. Coronavirus disease 2019 and the pancreas. Pancreatology. 2020;20:1567–1575. - PMC - PubMed
    1. Harmer D., Gilbert M., Borman R., Clark K.L. Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme. FEBS Lett. 2002;532(1–2):107–110. - PubMed