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. 2021 Jul:89:360-364.
doi: 10.1016/j.jocn.2021.05.047. Epub 2021 Jun 1.

Aggressive multiple sclerosis in Argentina: Data from the nationwide registry RelevarEM

Matías Kohler  1 Eduardo Kohler  1 Carlos Vrech  2 Agustín Pappolla  3 Jimena Miguez  3 Liliana Patrucco  3 Jorge Correale  4 Mariano Marrodan  4 María I Gaitán  4 Marcela Fiol  4 Laura Negrotto  4 María C Ysrraelit  4 Edgardo Cristiano  5 Adriana Carrá  6 Judith Steinberg  7 Alejandra D Martinez  7 María C Curbelo  7 Leila Cohen  8 Ricardo Alonso  9 Orlando Garcea  8 Cecilia Pita  8 Berenice Silva  8 Geraldine Luetic  10 Norma Deri  11 Maria E Balbuena  12 Verónica Tkachuk  12 Edgar Carnero Contentti  13 Pablo A Lopez  13 Juan P Pettinicchi  13 Alejandro Caride  13 Marcos Burgos  14 Felisa Leguizamon  15 Eduardo Knorre  15 Raúl Piedrabuena  16 Andrés Barboza  17 Susana Liwacki  18 Pedro Nofal  19 Gabriel Volman  20 Amelia Alvez Pinheiro  21 Javier Hryb  22 Dario Tavolini  23 Patricio Blaya  24 Luciano Recchia  25 Carolina Mainella  26 Emanuel Silva  27 Jorge Blanche  28 Santiago Tizio  29 Maria L Saladino  30 Fernando Caceres  30 Nora Fernandez Liguori  31 Luciana Lazaro  32 Gisela Zanga  33 Marcela Parada Marcilla  34 Maria E Fracaro  35 Fatima Pagani Cassara  36 Guido Vazquez  36 Vladimiro Sinay  36 Gustavo Sgrilli  37 Pablo Divi  38 Miguel Jacobo  38 Edgardo Reich  39 Lorena M Cabrera  40 María L Menichini  41 Mariano Coppola  42 Ivan Martos  43 Juan P Viglione  44 Gustavo Jose  45 Santiago Bestoso  46 Ruben Manzi  47 Diego Giunta  48 Maria L Doldan  5 Marina Alonso Serena  48 Juan I Rojas  49
Affiliations

Aggressive multiple sclerosis in Argentina: Data from the nationwide registry RelevarEM

Matías Kohler et al. J Clin Neurosci. 2021 Jul.

Abstract

The objectives of the present study were to describe the frequency of aggressive multiple sclerosis (aMS) as well as to compare clinical and radiological characteristics in aMS and non-aMS patients included in RelevarEM (NCT03375177).

Methods: The eligible study population and cohort selection included adult-onset patients (≥18 years) with definite MS. AMS were defined as those reaching confirmed EDSS ≥ 6 within 5 years from symptom onset. Confirmation was achieved when a subsequent EDSS ≥ 6 was recorded at least six months later but within 5 years of the first clinical presentation. AMS and non-aMS were compared using the χ2 test for categorical and the Mann-Whitney for continuous variables at MS onset and multivariable analysis was performed using forward stepwise logistic regression with baseline characteristics at disease onset.

Results: A total of 2158 patients with MS were included: 74 aMS and 2084 non-aMS. The prevalence of aMS in our cohort was 3.4% (95%CI 2.7-4.2). AMS were more likely to be male (p = 0.003), older at MS onset (p < 0.001), have primary progressive MS (PPMS) phenotype (p = 0.03), multifocal presentation (p < 0.001), and spinal cord as well as infratentorial lesions at MRI during disease onset (p = 0.004 and p = 0.002, respectively).

Conclusion: 3.4% of our patient population could be considered aMS. Men, patients older at symptom onset, multifocal presentation, PPMS phenotype, and spinal cord as well as brainstem lesions on MRI at clinical presentation all had higher odds of having aMS.

Keywords: Aggressive; Cohorts; Disease history; Multiple sclerosis; Registry.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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