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Meta-Analysis
. 2021 Jun 4;11(1):11865.
doi: 10.1038/s41598-021-91234-y.

Prognostic factors for mortality in invasive pneumococcal disease in adult: a system review and meta-analysis

Hao Chen  1 , Hiromi Matsumoto  2 , Nobuyuki Horita  2 , Yu Hara  2 , Nobuaki Kobayashi  2 , Takeshi Kaneko  2
Affiliations
Meta-Analysis

Prognostic factors for mortality in invasive pneumococcal disease in adult: a system review and meta-analysis

Hao Chen et al. Sci Rep. .

Abstract

Risk factors associated with mortality in invasive pneumococcal disease remain unclear. The present work is a meta-analysis of studies that enrolled only patients with invasive pneumococcal disease and reported on mortality. Potentially eligible reports were identified from PubMed, CHAHL, and Web of Science, comprising 26 reports in total. Overall mortality for invasive pneumococcal disease was reported as 20.8% (95% confidence interval (CI) 17.5-24%). Factors associated with mortality were age (odds ratio (OR) 3.04, 95% CI 2.5-3.68), nursing home (OR 1.62, 95% CI 1.13-2.32), nosocomial infection (OR 2.10, 95% CI 1.52-2.89), septic shock (OR 13.35, 95% CI 4.54-39.31), underlying chronic diseases (OR 2.34, 95% CI 1.78-3.09), solid organ tumor (OR 5.34, 95% CI 2.07-13.74), immunosuppressed status (OR 1.67, 95% CI 1.31-2.14), and alcohol abuse (OR 3.14, 95% CI 2.13-4.64). Mortality rates with invasive pneumococcal disease remained high, and these findings may help clinicians provide appropriate initial treatment for this disease.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
PRISMA flow chart for study selection.
Figure 2
Figure 2
Risk factor of Age > 64 years.
Figure 3
Figure 3
Risk factor of septic shock.
Figure 4
Figure 4
Risk factor of community-acquired infection versus.
See this image and copyright information in PMC

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