Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Jul;599(14):3435-3436.
doi: 10.1113/JP281785. Epub 2021 Jun 24.

The role of the SARS-CoV-2 envelope protein as a pH-dependent cation channel

Tomaž Trobec  1
Affiliations
Comment

The role of the SARS-CoV-2 envelope protein as a pH-dependent cation channel

Tomaž Trobec. J Physiol. 2021 Jul.
No abstract available

Keywords: SARS-CoV-2; electrophysiology; envelope protein; ion channel; pathophysiology.

PubMed Disclaimer

Comment on

References

    1. Cabrera‐Garcia D, Bekdash R, Abbott GW, Yazawa M & Harrison NL (2021). The envelope protein of SARS‐CoV‐2 increases intra‐Golgi pH and forms a cation channel that is regulated by pH. J Physiol 599, 2851–2868. - PMC - PubMed
    1. Das G, Das T, Chowdhury N, Chatterjee D, Bagchi A & Ghosh Z (2021). Repurposed drugs and nutraceuticals targeting envelope protein: a possible therapeutic strategy against COVID‐19. Genomics 113, 1129–1140. - PMC - PubMed
    1. McClenaghan C, Hanson A, Lee SJ & Nichols CG (2020). Coronavirus proteins as ion channels: current and potential research. Front Immunol 11, 573339 - PMC - PubMed
    1. Sarkar M & Saha S (2020). Structural insight into the role of novel SARS‐CoV‐2 E protein: a potential target for vaccine development and other therapeutic strategies. PLoS One 15, e0237300. - PMC - PubMed
    1. Singh Tomar PP & Arkin IT (2020). SARS‐CoV‐2 E protein is a potential ion channel that can be inhibited by gliclazide and memantine. Biochem Biophys Res Commun 530, 10–14. - PMC - PubMed

Publication types