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Review
. 2021 Aug;6(8):668-675.
doi: 10.1016/S2468-1253(21)00019-4. Epub 2021 Jun 3.

Diabetes following acute pancreatitis

Phil A Hart  1 , David Bradley  2 , Darwin L Conwell  3 , Kathleen Dungan  2 , Somashekar G Krishna  3 , Kathleen Wyne  2 , Melena D Bellin  4 , Dhiraj Yadav  5 , Dana K Andersen  6 , Jose Serrano  6 , Georgios I Papachristou  3
Affiliations
Review

Diabetes following acute pancreatitis

Phil A Hart et al. Lancet Gastroenterol Hepatol. 2021 Aug.

Abstract

Diabetes represents a group of diseases involving persistent hyperglycaemia. Exocrine disorders of the pancreas are increasingly recognised to cause or precede the onset of diabetes, which in this context is referred to as pancreatogenic or type 3c diabetes. Diabetes, as a sequela of acute pancreatitis, is observed across the spectrum of severity in acute pancreatitis and can be associated with other clinical complications. The pathophysiology of acute pancreatitis-related diabetes is poorly understood, and observations suggest that it is probably multifactorial. In this Review, we discuss the epidemiology, pathophysiology, and management considerations of diabetes following acute pancreatitis, and highlight knowledge gaps in this topic.

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Conflict of interest statement

Declaration of interests We declare no competing interests.

Figures

Figure.
Figure.
Proposed contributing factors to the pathophysiology of diabetes following acute pancreatitis (acute pancreatitis-related diabetes mellitus), including potential mechanisms of dysglycemia. HTG, hypertriglyceridemia.
See this image and copyright information in PMC

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