Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2021 Jun 5;16(1):161.
doi: 10.1186/s13019-021-01550-7.

The effect of N-acetyl cysteine injection on renal function after coronary artery bypass graft surgery: a randomized double blind clinical trial

Fatemeh Javaherforooshzadeh  1 , Zahra Shaker  2 , Mahboobeh Rashidi  2 , Reza Akhondzadeh  2 , Fatemeh Hayati  3
Affiliations
Randomized Controlled Trial

The effect of N-acetyl cysteine injection on renal function after coronary artery bypass graft surgery: a randomized double blind clinical trial

Fatemeh Javaherforooshzadeh et al. J Cardiothorac Surg. .

Abstract

Background: This study aimed to compare the effects of N-acetyl cysteine on renal function after coronary artery bypass graft surgery.

Methods: In this randomized clinical trial conducted in Golestan Hospital, Ahvaz, Iran, 60 candidates for coronary artery bypass graft surgery were selected and divided into two N-acetyl cysteine and control groups (30 people each). Patients received 3 (2 intraoperative and 1 postoperative) doses of IV N-acetyl cysteine (100 mg/kg) (n = 30) or placebo (n = 30) over 24 h. Prescription times were as follows: after induction of anesthesia, in the Next 4 h, and in the 16 h after on. Primary outcomes were serum levels of BUN and Cr, at baseline,4 and 48 h after surgery. And also need renal replacement therapy (RRT). Secondary outcomes included the hemodynamic variables, Blood products transfusion.

Results: There were significant differences in BUN between groups at 4 h (P = 0.02) and 48 h after surgery (P = 0.001) There were significant differences in Cr level between groups at 4 h (P < 0.001) and 48 h after surgery (P = 0.001). MAP at different times (at 4 h p = 0.002 and 48 h after surgery P < 0.001) were significantly different between the two groups. There was a significant difference between the two groups in terms of the unit of Packed cell transfusion (P = 0.002) and FFP transfusion (P < 0.001).

Conclusion: In the present study, we found that administration of N-acetyl cysteine can reduce the incidence of acute kidney injury in patients undergoing coronary artery bypass graft surgery and improved kidney functions.

Trial registry: IRCT20190506043492N3 Registered at 2020.06.07.

Keywords: Acute kidney injury; Coronary artery bypass graft surgery; N-acetyl-cysteine.

PubMed Disclaimer

Conflict of interest statement

There is no conflict of interest to be declared.

Figures

Fig. 1
Fig. 1
Eighty subjects were enrolled in the study, of which 60 met the criteria for the study and consented to participate. Participants were divided into two groups (each with 30 subjects)
See this image and copyright information in PMC

References

    1. Abramov D, Tamariz MG, Fremes SE, Guru V, Borger MA, Christakis GT, Bhatnagar G, Sever JY, Goldman BS. Trends in coronary artery bypass surgery results: a recent, 9-year study. Ann Thorac Surg. 2000;70(1):84–90. doi: 10.1016/S0003-4975(00)01249-2. - DOI - PubMed
    1. Kwon J-T, Jung T-E, Lee D-H. Predictive risk factors of acute kidney injury after on-pump coronary artery bypass grafting. Ann Transl Med. 2019;7(3):44. doi: 10.21037/atm.2018.12.61. - DOI - PMC - PubMed
    1. Javaherforooshzadeh F, Bhandori H, Jarirahmadi S, Bakhtiari N. Investigating the Effect of Near Infra-Red Spectroscopy (NIRS) on Early Diagnosis of Cardiac Surgery-Associated Acute Kidney Injury. Anesthesiol Pain Med. 2020;10(6). 10.5812/aapm.109863. - PMC - PubMed
    1. Ortega-Loubon C, Fernández-Molina M, Carrascal-Hinojal Y, Fulquet-Carreras E. Cardiac surgery-associated acute kidney injury. Ann Card Anaesth. 2016;19(4):687–698. doi: 10.4103/0971-9784.191578. - DOI - PMC - PubMed
    1. Doi K, Nishida O, Shigematsu T, Sadahiro T, Itami N, Iseki K, et al. The Japanese clinical practice guideline for acute kidney injury 2016. J Intensive Care. 2018;6(1):48. doi: 10.1186/s40560-018-0308-6. - DOI - PMC - PubMed

Publication types

MeSH terms