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. 2021 Aug 15:357:577561.
doi: 10.1016/j.jneuroim.2021.577561. Epub 2021 Mar 30.

Involvement and relationship of bacterial lipopolysaccharides and cyclooxygenases levels in Alzheimer's Disease and Mild Cognitive Impairment patients

Eleni G Andreadou  1 , Georgios Katsipis  2 , Magda Tsolaki  3 , Anastasia A Pantazaki  4
Affiliations

Involvement and relationship of bacterial lipopolysaccharides and cyclooxygenases levels in Alzheimer's Disease and Mild Cognitive Impairment patients

Eleni G Andreadou et al. J Neuroimmunol. .

Abstract

This study reports elevated levels of bacterial lipopolysaccharides (LPSs) and cyclooxygenases (COX-1/2) in blood serum and cerebrospinal fluid (CSF) of Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) patients compared to cognitively healthy individuals, indicating LPSs as promising biomarkers, especially in serum. LPSs, in both fluids, positively correlate with COX-1/2, Αβ42 and tau and negatively with mental state. Furthermore, COX-2 is the main determinant of LPSs presence in serum, whereas COX-1 in CSF. These results underline the significance of microbial/ inflammatory involvement in dementia and offer novel perspectives on the roles of LPSs and COX in pathogenesis of AD.

Keywords: Alzheimer's Disease; Biomarkers; Cyclooxygenases; Inflammation; Lipopolysaccharides; Mild Cognitive Impairment.

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