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. 2022 Feb;190(3):e503.
doi: 10.1002/vetr.503. Epub 2021 Jun 6.

Use of a modified Burow's solution to treat canine otitis externa: A randomised comparative clinical study

Sam Sadeghi  1 , Alireza Kamrani  1 , Urszula Kuc  1 , Nayak Polissar  2 , Subodh Selukar  2 , Sina Sadeghi  1
Affiliations

Use of a modified Burow's solution to treat canine otitis externa: A randomised comparative clinical study

Sam Sadeghi et al. Vet Rec. 2022 Feb.

Abstract

Background: Given the increase in antimicrobial drug resistance of several pathogens that affect the ear, there is a need for alternative therapy for canine otitis externa (OE). We hypothesised that the efficacy of modified Burow's solution would be non-inferior to that of standard treatment with Surolan.

Methods: The treatment success rate of a topical aluminum acetate 2% and betamethasone 0.1% (modified Burow's) otic solution was compared with that of a standard topical otic treatment of polymyxin B sulfate, prednisolone acetate and miconazole (Surolan) suspension in a prospective, open-label clinical trial. For 10 days, 142 dogs (232 ears) with OE were treated with modified Burow's solution or Surolan. The primary study endpoint was the cure rate at 10 days. Clinical efficacy was analysed as a secondary endpoint but without assessment for non-inferiority.

Results: The 10-day OE cure rate was 65% and 59% in the Burow's and Surolan groups, respectively. The modified Burow's solution was non-inferior to Surolan at a non-inferiority margin of -11.5% and was more clinically effective than Surolan in dogs with OE caused by yeast or bacteria.

Conclusion: The results of this study demonstrate that modified Burow's solution is an effective treatment for OE in dogs.

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References

REFERENCES

    1. Maruhashi E, Braz BS, Nunes T, Pomba C, Belas A, Duarte-Correia JH et al., Efficacy of medical grade honey in the management of canine otitis externa - a pilot study. Vet Dermatol. 2016;27:93-8e27.
    1. De Bock M, Engelen M, Hare J, Goossens L. Effectiveness of an otic product containing miconazole, polymyxin B and prednisolone in the treatment of canine otitis externa: multi-site field trial in the US and Canada. Int J Appl Res Vet Med. 2008;8:21-30.
    1. Koch SN. Aluminium acetate solution (Burow's solution). In: Plumb D, editor. Plum's veterinary drug handbook. 9th ed., USA: John Wiley & Sons Inc.; 2018. p. 1823-4.
    1. Serin GM, Ciprut A, Baylançiçek S, Sari M, Akdaş F, Tutkun A. Ototoxic effect of Burow solution applied to the guinea pig middle ear. Otol Neurotol. 2007;28:605-8.
    1. Terayama Y, Takizawa M, Gotouda H, Sutou S, Kashiwamura M. Effects of Burow's solution as an ear drop on intractable chronic suppurative diseases of the external ear canal and middle ear. Nihon Jibiinkoka Gakkai Kaiho. 2003;106:28-33.

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