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Review
. 2021 Jul;50(6):565-571.
doi: 10.1111/jop.13207. Epub 2021 Jun 20.

Langerhans cell histiocytosis in the oral and maxillofacial region: An update

Isabel Schausltz Pereira Faustino  1 , Patrícia Maria Fernandes  1 , Hélder Antônio Rebelo Pontes  2 , Adalberto Mosqueda-Taylor  3 , Alan Roger Santos-Silva  1 , Pablo Agustin Vargas  1 , Marcio Ajudarte Lopes  1
Affiliations
Review

Langerhans cell histiocytosis in the oral and maxillofacial region: An update

Isabel Schausltz Pereira Faustino et al. J Oral Pathol Med. 2021 Jul.

Abstract

Background: Langerhans cell histiocytosis (LCH) is a rare disorder characterized by abnormal proliferation and infiltration of histiocytic cells.

Methods: This review focused on the main aspects associated with LCH.

Results: LCH can involve single or multiple organs and systems, with bone and skin being the most commonly affected sites. Regarding skeletal manifestations, the jawbones are involved in about 20%-30% of all cases. Such lesions may present as unilocular or multilocular images mainly affecting the posterior mandible. Oral soft tissue lesions may also occur, with the gingiva and hard palate being the most frequently affected sites.

Conclusion: The diagnosis and management of LCH are challenging, requiring a multidisciplinary approach, with dentists playing a central role since oral manifestations can be the first sign of the condition.

Keywords: Eosinophilic granuloma; Hand-Schuller-Christian Disease; Langerhans Cell; Letterer-Siwe Disease; histiocytosis; histiocytosis X.

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