Airway smooth muscle pathophysiology in asthma

Abstract

The airway smooth muscle (ASM) cell plays a central role in the pathogenesis of asthma and constitutes an important target for treatment. These cells control muscle tone and thus regulate the opening of the airway lumen and air passage. Evidence indicates that ASM cells participate in the airway hyperresponsiveness as well as the inflammatory and remodeling processes observed in asthmatic subjects. Therapeutic approaches require a comprehensive understanding of the structure and function of the ASM in both the normal and disease states. This review updates current knowledge about ASM and its effects on airway narrowing, remodeling, and inflammation in asthma.

Keywords: Airway smooth muscle; airway remodeling; asthma; bitter taste receptors; bronchial thermoplasty; bronchoconstriction; bronchodilation; deep inspiration; epigenetics; genetics; inflammation; olfactory receptors.