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. 2021 Jun 29;39(29):3790-3793.
doi: 10.1016/j.vaccine.2021.05.087. Epub 2021 May 28.

Myocarditis following COVID-19 mRNA vaccination

Saif Abu Mouch  1 , Ariel Roguin  2 , Elias Hellou  2 , Amorina Ishai  3 , Uri Shoshan  4 , Lamis Mahamid  5 , Marwan Zoabi  4 , Marina Aisman  6 , Nimrod Goldschmid  7 , Noa Berar Yanay  8
Affiliations

Myocarditis following COVID-19 mRNA vaccination

Saif Abu Mouch et al. Vaccine. .

Abstract

Background: Clinical trials of the BNT162b2 vaccine, revealed efficacy and safety. We report six cases of myocarditis, which occurred shortly after BNT162b2 vaccination.

Methods: Patients were identified upon presentation to the emergency department with symptoms of chest pain/discomfort. In all study patients, we excluded past and current COVID-19. Routine clinical and laboratory investigations for common etiologies of myocarditis were performed. Laboratory tests also included troponin and C-reactive protein levels. The diagnosis of myocarditis was established after cardiac MRI.

Findings: Five patients presented after the second and one after the first dose of the vaccine. All patients were males with a median age of 23 years. Myocarditis was diagnosed in all patients, there was no evidence of COVID-19 infection. Laboratory assays excluded concomitant infection; autoimmune disorder was considered unlikely. All patients responded to the BNT162b2 vaccine. The clinical course was mild in all six patients.

Interpretation: Our report of myocarditis after BNT162b2 vaccination may be possibly considered as an adverse reaction following immunization. We believe our information should be interpreted with caution and further surveillance is warranted.

Keywords: Adverse reaction; BNT162b2; Covid-19; Myocarditis; Vaccine.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Abnormal ECG recording, showing diffuse PR depression and diffuse ST segment elevation.
Fig. 2
Fig. 2
Short axis late gadolinium enhancement image. Mid-myocardial enhancement of the middle inferolateral and anterolateral wall consistent with myo-pericarditis. (Red arrows point to LGE). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)
See this image and copyright information in PMC

Comment in

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