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. 1977 Dec 9;157(3):313-8.
doi: 10.1007/BF00268668.

The role of misrepair processes in the isolation of new types of streptomycin-resistant mutants in Escherichia coli

L Lacoste, M Lacaille, L Brakier-Gingras

The role of misrepair processes in the isolation of new types of streptomycin-resistant mutants in Escherichia coli

L Lacoste et al. Mol Gen Genet. .

Abstract

Treatment of Escherichia coli cells with ethylmethanesulfonate followed by a prolonged delay for phenotypic expression allows to select new types of streptomycin-resistant mutants, which are double mutants with one change resulting from base mispairing and the second one from misrepair. The error-prone recA-dependent pathway is involved in this misrepair, as evidenced by the fact that recA strains do not provide double mutants.

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