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. 2021 Oct 1:300:130167.
doi: 10.1016/j.matlet.2021.130167. Epub 2021 Jun 2.

Synthesis of dual-phase Ti3O5/Ti4O7 nanofibers for efficient adsorption of SARS-CoV-2

Zhanlin Ding  1   2 , Hong Wang  1 , Zhe Feng  1 , Meiqing Sun  1
Affiliations

Synthesis of dual-phase Ti3O5/Ti4O7 nanofibers for efficient adsorption of SARS-CoV-2

Zhanlin Ding et al. Mater Lett. .

Abstract

In this study, we synthesized the dual-phase Ti3O5/Ti4O7 nanofibers for efficient adsorption of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a life-threatening virus being taking millions of people lives. The Ti3O5/Ti4O7 nanofibers were synthesized by preparation of H2Ti3O7 precursor, polydopamine coating and furnace calcination. Protein and phospholipid adsorption assays showed that the dual-phase nanofibers had much higher affinity to both the model molecules bovine serum album (BSA) and phosphatidylethanolamine (PE) than the control single-phase Ti6O11 nanofibers. Consistently, the dual-phase nanofibers exhibited much stronger adsorption ability to SARS-CoV-2 pseudovirus than Ti6O11. This study sheds a light on titanium oxide nanomaterials to adsorb SARS-CoV-2 for avoiding its infection and for capturing it during rapid virus detection.

Keywords: Adhesion; Nanomaterials; Nanoparticles; SARS-CoV-2.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

None
Graphical abstract
Fig. 1
Fig. 1
Characterization of the Ti3O5/Ti4O7 nanofibers. (a) SEM images. (b) TEM images. (c) XRD spectrum. (d) XPS spectrum. (e) FT-IR spectrum.
Fig. 2
Fig. 2
Adsorption ability of the nanofibers to BSA and PE. (a) BSA adsorption by the nanofibers. (b) PE adsorption by the nanofibers. * indicates significant difference between the groups (P < 0.05).
Fig. 3
Fig. 3
Adsorption ability of the nanofibers to the SARS-CoV-2 pseudovirus. (a) Confocal microscope images of the nanofibers after pseudovirus adsorption and staining by FITC-tagged anti-S protein antibody, which specifically binds S protein and therefore indicates pseudovirus distribution. (b) Amplification curve of the SARS-CoV-2 pseudovirus gene marker in filtered liquid samples after adsorption by the nanofibers. (c) Droplet digital PCR results of the filtered liquid samples. The numbers indicate the left virus in the filtered liquids.
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