Recent Advances in the Potential Use of Circular RNA for the Diagnosis and Treatment of Pancreatic Cancer

doi:10.2147/CMAR.S308809

Review

. 2021 May 28:13:4251-4262.

doi: 10.2147/CMAR.S308809. eCollection 2021.

Recent Advances in the Potential Use of Circular RNA for the Diagnosis and Treatment of Pancreatic Cancer

Xinzhu Sun¹, Dongyan Liu², Nan Ge¹, Jintao Guo¹, Sheng Wang¹, Xiang Liu¹, Guoxin Wang¹, Siyu Sun¹

Affiliations

¹ Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
² Department of Gastroenterology and Medical Research Center, Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.

PMID: 34093039
PMCID: PMC8168960
DOI: 10.2147/CMAR.S308809

Review

Recent Advances in the Potential Use of Circular RNA for the Diagnosis and Treatment of Pancreatic Cancer

Xinzhu Sun et al. Cancer Manag Res. 2021.

. 2021 May 28:13:4251-4262.

doi: 10.2147/CMAR.S308809. eCollection 2021.

Authors

Xinzhu Sun¹, Dongyan Liu², Nan Ge¹, Jintao Guo¹, Sheng Wang¹, Xiang Liu¹, Guoxin Wang¹, Siyu Sun¹

Affiliations

¹ Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
² Department of Gastroenterology and Medical Research Center, Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.

PMID: 34093039
PMCID: PMC8168960
DOI: 10.2147/CMAR.S308809

Abstract

There are few biomarkers available for the early diagnosis and prognostic evaluation of pancreatic cancer. In addition, the development of targeted therapy for pancreatic cancer is an unmet need due to the lack of molecular targets. With the continuous progress in circular RNA (circRNA)-related research, its role in the occurrence and development of pancreatic cancer has been discovered and gradually recognized. Therefore, circRNA may represent a novel marker for early diagnosis of this disease and a focus of targeted clinical therapy. CircRNA is a type of non-coding RNA with a closed circular structure formed by covalent bonds. Some circRNAs can act as "sponges" to adsorb microRNAs (miRNAs) and play the role of competitive endogenous RNA (ceRNA) to remove their inhibitory effects on the target genes of miRNA. Thus, they can indirectly restore the expression of target genes. The circRNA-miRNA-mRNA network plays a regulatory role in the proliferation, invasion, metastasis, and other biological behaviors of pancreatic cancer. Given the recent advances in circRNA, this review seeks to provide an overview of the biological function of circRNA and highlights the recent research progress regarding the molecular mechanism of circRNA for the clinical diagnosis and treatment of pancreatic cancer.

Keywords: biological function; biomarker; circular RNA; pancreatic cancer; targeted therapy.

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Conflict of interest statement

Dr Nan Ge reports grants from Natural Science Foundation of Liaoning Province (Grant No. 20180530014), during the conduct of the study; Dr Jintao Guo report grants from National Natural Science Foundation of China (Grant No. 81900601), during the conduct of the study. Dr Siyu Sun reports grants from University innovation team and innovative talent support program of Liaoning Province (Grant No. LR2019073), from Outstanding Scientific Fund of Shengjing Hospital (Grant No. 201701), during the conduct of the study. The authors report no conflicts of interest in this work.

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References

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[1] Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 2019;20(11):675–691. doi:10.1038/s41576-019-0158-7 - DOI - PubMed

[2] Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 2019;20(11):675–691. doi:10.1038/s41576-019-0158-7 - DOI - PubMed

[3] Sanger HL, Klotz G, Riesner D, Gross HJ, Kleinschmidt AK. Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci U S A. 1976;73(11):3852–3856. doi:10.1073/pnas.73.11.3852 - DOI - PMC - PubMed

[4] Sanger HL, Klotz G, Riesner D, Gross HJ, Kleinschmidt AK. Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. Proc Natl Acad Sci U S A. 1976;73(11):3852–3856. doi:10.1073/pnas.73.11.3852 - DOI - PMC - PubMed

[5] Hsu MT, Coca-Prados M. Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells. Nature. 1979;280(5720):339–340. doi:10.1038/280339a0 - DOI - PubMed

[6] Hsu MT, Coca-Prados M. Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells. Nature. 1979;280(5720):339–340. doi:10.1038/280339a0 - DOI - PubMed

[7] Arnberg AC, Van Ommen GJ, Grivell LA, Van Bruggen EF, Borst P. Some yeast mitochondrial RNAs are circular. Cell. 1980;19(2):313–319. doi:10.1016/0092-8674(80)90505-X - DOI - PubMed

[8] Arnberg AC, Van Ommen GJ, Grivell LA, Van Bruggen EF, Borst P. Some yeast mitochondrial RNAs are circular. Cell. 1980;19(2):313–319. doi:10.1016/0092-8674(80)90505-X - DOI - PubMed

[9] Wang PL, Bao Y, Yee MC, et al. Circular RNA is expressed across the eukaryotic tree of life. PLoS One. 2014;9(6):e90859. doi:10.1371/journal.pone.0090859 - DOI - PMC - PubMed

[10] Wang PL, Bao Y, Yee MC, et al. Circular RNA is expressed across the eukaryotic tree of life. PLoS One. 2014;9(6):e90859. doi:10.1371/journal.pone.0090859 - DOI - PMC - PubMed

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Recent Advances in the Potential Use of Circular RNA for the Diagnosis and Treatment of Pancreatic Cancer

Affiliations

Recent Advances in the Potential Use of Circular RNA for the Diagnosis and Treatment of Pancreatic Cancer

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Conflict of interest statement

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Abstract

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