Relative Children's Lipid Accumulation Product Is a Novel Indicator for Metabolic Syndrome

Abstract

Background: The children's lipid accumulation product (CLAP) is associated with MS in Chinese children and adolescents. The aim of this study was to develop a more effective indicator, the relative children's lipid accumulation product (RCLAP) was evaluated for correlation with MS and the density of lipid accumulation.

Methods: A stratified cluster sampling method was used to recruit 683 students aged 8-15 years in this study. The presence of MS was defined according to the NCEP-ATP III criteria. The participants' guardians signed informed consent before the medical examination. This study was approved by the Medical Ethics Committee of the Bengbu Medical College [(2015) No.003] and was conducted in accordance with the Declaration of Helsinki.

Results: The overall prevalence of MS was 4.8% (male 6.6%, female 2.8%). After adjusting for sedentary activity time, relative children's lipid accumulation product per height (RCLAP-H) and relative children's lipid accumulation product per sitting height (RCLAP-SH) significantly increased the risk of MS in girls [OR (95% CI): 96.13 (11.11-831.97) and 96.13 (11.11-831.97), respectively]. After adjusting for ages and moderate-to-vigorous physical activity time, RCLAP-H, and RCLAP-SH significantly increased the risk of MS in boys [OR (95% CI): 171.75 (33.60-878.00) and 133.18 (27.65-641.39), respectively]. The AUCs of RCLAP-H and RCLAP-SH for predicting MS were 0.950, 0.948 in girls, and 0.952, 0.952 in boys, which were higher than BMI, WHtR, Tg/HDL-C, CLAP, and CLAP combining height, sitting height.

Conclusions: The RCLAP-H and RCLAP-SH were more effective indicators for predicting MS than BMI, WHtR, Tg/HDL-C, and CLAP in children and adolescents.

Keywords: adolescents; children; metabolic syndrome; obesity; relative children’s lipid accumulation product.

Figure 1

ROC curves of SBMI, SWHtR STg/HDL-C, SlnCLAP SRCLAP-H, SRCLAP-SH, SRCLAP-W, SlnCLAP combining SH, SlnCLAP combining SSH, SlnCLAP combining SW to predict MS among boys and girls. SBMI, standardized body mass index; SWHtR, waist-height ratio; STg/HDL-C, triglycerides-to-HDL-C ratio; SlnCLAP, logarithmic children’s lipid accumulation product; SRCLAP-H, relative children’s lipid accumulation product per height; SRCLAP-SH, relative children’s lipid accumulation product per sitting height; SRCLAP-W, relative children’s lipid accumulation product per weight by sex and age using the z-score method.