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Editorial
. 2021 May 19:12:699069.
doi: 10.3389/fimmu.2021.699069. eCollection 2021.

Editorial: Purinergic Signaling and Inflammation

Xiaoyi Yuan  1 , Davide Ferrari  2 , Tingting Mills  3 , Yanyu Wang  1 , Agnieszka Czopik  1 , Marie-Francoise Doursout  1 , Scott E Evans  4 , Marco Idzko  5 , Holger K Eltzschig  1
Affiliations
Editorial

Editorial: Purinergic Signaling and Inflammation

Xiaoyi Yuan et al. Front Immunol. .
No abstract available

Keywords: ATP receptors; adenosine receptors; inflammation; mucosal inflammation; purinergic signaling.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Extracellular nucleotide release and signalling during inflammation. During inflammation, multiple cell types release nucleotides, for example ATP or ADP, from their intracellular compartments into the extracellular space. Nucleotides can be released during mechanical injury, necrosis, apoptosis or inflammatory cell activation. Several molecular pathways have been implicated in this process, such as vesicular ADP release from platelets, pannexin-mediated ATP release during apoptosis, and connexin- or pannexin-mediated ATP release from inflammatory cells, such as neutrophils. Extracellular nucleotides function as signalling molecules through the activation of purinergic P2 receptors. These receptors can be grouped into metabotropic P2Y receptors (P2YRs; GPCRs with seven transmembrane-spanning motifs) or ionotropic P2X receptors (P2XRs), which are nucleotide-gated ion channels. Each P2XR is formed by three subunits (P2XR monomers), each of which consists of two transmembrane regions, TM1 and TM2. Binding of three molecules of ATP to the assembled P2X channel causes opening of a central pore. These conformational changes allow for flux of ions such as sodium (Na+), calcium (Ca2+) and potassium (K+) across the membrane. ATP signalling is terminated by the enzymatic conversion of ATP to adenosine through the ectonucleoside triphosphate diphosphohydrolase CD39 (conversion of ATP/ADP to AMP) and the ecto-5′-nucleotidase CD73 (conversion of AMP to adenosine). Similar to ATP, adenosine (A) functions as an extracellular signalling molecule through the activation of purinergic P1 adenosine receptors. Material from: Idzko et al. (1). Reprinted with permission.
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  • Editorial on the Research Topic Purinergic Signaling and Inflammation

References

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