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Case Reports
. 2021 May 12:2021:9920817.
doi: 10.1155/2021/9920817. eCollection 2021.

Tolvaptan Response in a Hyponatremic Newborn with Syndrome of Inappropriate Secretion of Antidiuretic Hormone

Cengiz Zeybek  1 , Ali Dinç Bozat  2 , Erhan Calisici  2 , Ahmet Bolat  3 , Belma Saygili Karagol  2
Affiliations
Case Reports

Tolvaptan Response in a Hyponatremic Newborn with Syndrome of Inappropriate Secretion of Antidiuretic Hormone

Cengiz Zeybek et al. Case Rep Pediatr. .

Abstract

The use of tolvaptan to treat both euvolemic and hypervolemic hyponatremia has rapidly increased in recent years. However, data on its effects on children, especially newborns and infants, are limited. Here, we present a newborn who developed syndrome of inappropriate secretion of antidiuretic hormone following an intracranial hematoma drainage operation who was unresponsive to conventional treatments. The infant was successfully treated with tolvaptan, a competitive inhibitor of the vasopressin V2 receptor.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Serum sodium and urinary output before and after single-dose tolvaptan treatment. The black arrow indicates the day on which tolvaptan was administered.
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