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. 2021 May 19:11:654784.
doi: 10.3389/fonc.2021.654784. eCollection 2021.

Significant Association Between XRCC1 Expression and Its rs25487 Polymorphism and Radiotherapy-Related Cancer Prognosis

Li Gong  1 , Ming Luo  1 , Renhuang Sun  1 , Li Qiu  1 , Chunli Chen  1 , Zhiguo Luo  1   2
Affiliations

Significant Association Between XRCC1 Expression and Its rs25487 Polymorphism and Radiotherapy-Related Cancer Prognosis

Li Gong et al. Front Oncol. .

Abstract

Background/aims: XRCC1 (X-ray repair cross-complementing protein 1) expression and its single nucleotide polymorphism XRCC1 rs25487 (G>A) may be related to radiotherapy-related cancer prognosis or radiation-induced side effects. However, this association is controversial. We performed a bioinformatic analysis and a meta-analysis to obtain comprehensive results.Methods: TCGA data sets and eligible publications published before November 31, 2020 were retrieved by searching the PubMed, Web of Science and CNKI (China National Knowledge Infrastructure) databases. ORs (odds ratios) and HRs (hazard ratios) with their corresponding 95% CIs (confidence intervals) were calculated to evaluate associations. For XRCC1 single nucleotide polymorphisms, we employed three types of comparisons: GA vs GG, AA vs GG and GA+AA vs GG.

Results: Sixty nine articles with 10232 patients and 17 TCGA data sets with 2705 patients were included in the analysis. We observed that high XRCC1 expression was associated with an increased risk of minor treatment response and poor overall survival, XRCC1 rs25487 was associated with reduced risk of minor treatment response in esophageal cancer and an increased risk of high-grade side effects in head and neck cancer.

Conclusion: The results suggest that XRCC1 expression and rs25487 polymorphism are prognostic factors for patients receiving radiotherapy-related treatment. Considering the insufficient treatment parameters provided and the various sample sizes in most of the studies, we suggest that genetic association studies related to radiation-based treatment should include more cancer types with sufficient statistical power and more detailed clinical parameters.

Keywords: XRCC1; overall survival; radiation; rs25487; side-effects; treatment response.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The flow diagram of study inclusion. In total, 301 articles were identified using the searching strategy. Of these, 207 articles were excluded because they do not report the association. Then, five articles were excluded due to duplication. Finally, 69 articles were included in meta-analysis. The flow diagram of study inclusion was cited from Moher et al. (18).
Figure 2
Figure 2
Overall survival of XRCC1 expression in TCAG data set.
See this image and copyright information in PMC

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References

    1. Cosh A, Carslaw H. What does a GP need to know about radiotherapy? Innovait (2014) 7(6):349–55. 10.1177/1755738013484908 - DOI
    1. Al-Sukhni E, Attwood K, Mattson DM, Gabriel E, Nurkin SJ. Predictors of Pathologic Complete Response Following Neoadjuvant Chemoradiotherapy for Rectal Cancer. Ann Surg Oncol (2016) 23(4):1177–86. 10.1245/s10434-015-5017-y - DOI - PMC - PubMed
    1. Bentzen SM, Overgaard J. Patient-to-Patient Variability in the Expression of Radiation-Induced Normal Tissue Injury. Semin Radiat Oncol (1994) 4(2):68–80. 10.1016/S1053-4296(05)80034-7 - DOI - PubMed
    1. Wang M, Delasalle K, Feng L, Thomas S, Giralt S, Qazilbash M, et al. . CR represents an early index of potential long survival in multiple myeloma. Bone Marrow Transplant (2010) 45(3):498–504. 10.1038/bmt.2009.176 - DOI - PMC - PubMed
    1. Kerns SL, West CM, Andreassen CN, Barnett GC, Bentzen SM, Burnet NG, et al. . Radiogenomics: the search for genetic predictors of radiotherapy response. Future Oncol (London England) (2014) 10(15):2391–406. 10.2217/fon.14.173 - DOI - PubMed

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