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. 2021 May 21:11:689562.
doi: 10.3389/fonc.2021.689562. eCollection 2021.

The Global, Regional, and National Burden and Trends of Breast Cancer From 1990 to 2019: Results From the Global Burden of Disease Study 2019

Shangbo Xu  1 , Yiyuan Liu  2   3 , Taofeng Zhang  2   3 , Jiehua Zheng  2   3 , Weixun Lin  2   3 , Jiehui Cai  2   3 , Juan Zou  2   3 , Yaokun Chen  2   3 , Yanna Xie  4   3 , Yexi Chen  2   3 , Zhiyang Li  2
Affiliations

The Global, Regional, and National Burden and Trends of Breast Cancer From 1990 to 2019: Results From the Global Burden of Disease Study 2019

Shangbo Xu et al. Front Oncol. .

Abstract

Background: The burden of breast cancer has been increasing globally. The epidemiology burden and trends need to be updated. This study aimed to update the burden and trends of breast cancer incidences, deaths, and disability-adjusted life-years (DALYs) from 1990 to 2019, using the Global Burden of Disease 2019 study.

Methods: The data of incidences, deaths, DALYs, and age-standardized rates were extracted. Estimated annual percentage changes were used to quantify the trends of age-standardized rates. Besides, the population attributable fractions of the risk factors of breast cancer were also estimated.

Results: Globally, the incidences of breast cancer increased to 2,002,354 in 2019. High social-development index (SDI) quintiles had the highest incidence cases with a declining trend in age-standardized incidence rate. In 2019, the global deaths and DALYs of breast cancer increased to 700,660 and 20,625,313, respectively. From 1990 to 2019, the age-standardized mortality rates and age-standardized DALY rates declined globally, especially in high and high-middle SDI quintiles. Besides, the trends varied from different regions and countries. The proportion of the patients in the 70+ years age group increased globally. Deaths of breast cancer attributable to high fasting plasma glucose and high body mass index increased globally, and high fasting plasma glucose was the greatest contributor to the global breast cancer deaths.

Conclusion: The burden of breast cancer in higher SDI quintiles had gone down while the burden was still on the rise in lower SDI quintiles. It is necessary to appeal to the public to decrease the exposure of the risk factors.

Keywords: breast cancer; global cancer burden; incidence; mortality; risk factor.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The estimated annual percentage changes (EAPCs) of breast cancer in 204 countries and territories between 1990 and 2019. (A) The EAPC of age-standardized incidence rates (ASIR). (B) The EAPC of age-standardized mortality rates (ASMR). (C) The EAPC of age-standardized disability-adjusted life-year (DALY) rates.
Figure 2
Figure 2
Age-standardized incidence rates (ASIR) for breast cancer for 21 Global Burden of Disease (GBD) regions by Socio-Demographic Index (SDI), 1990–2019; expected values based on SDI and disease rates in all locations are shown as the black line. Thirty points are plotted for each GBD region and show observed ASIR from 1990 to 2017 for that region. The R indices and P value were derived from Pearson correlation analysis.
Figure 3
Figure 3
Age-standardized incidence rates (ASIR) of breast cancer by 204 countries and territories and Socio-Demographic Index (SDI), 2019; expected values are shown as the black line. Each point shows observed ASIR for specified country in 2019. The R indices and P value were derived from Pearson correlation analysis.
Figure 4
Figure 4
The proportion of the three age groups (15–49 years, 50–69 years, and 70+ years) for breast cancer incidence cases between 1990 and 2019 globally, and in high, high middle, middle, low middle, and low Socio-Demographic Index (SDI) quintiles.
Figure 5
Figure 5
Contributions of different risk factors to breast cancer deaths globally and in five sociodemographic index (SDI) quintiles from 1990 to 2019.
See this image and copyright information in PMC

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