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. 2021 Jan 18;5(3):390-398.
doi: 10.1002/ags3.12428. eCollection 2021 May.

Osteosarcopenia is a potential predictor for the prognosis of patients who underwent hepatic resection for colorectal liver metastases

Kenei Furukawa  1 , Koichiro Haruki  1 , Tomohiko Taniai  1 , Ryoga Hamura  1 , Yoshihiro Shirai  1 , Jungo Yasuda  1 , Hironori Shiozaki  1 , Shinji Onda  1 , Takeshi Gocho  1 , Toru Ikegami  1
Affiliations

Osteosarcopenia is a potential predictor for the prognosis of patients who underwent hepatic resection for colorectal liver metastases

Kenei Furukawa et al. Ann Gastroenterol Surg. .

Abstract

Aim: We investigated the prognostic impact of osteosarcopenia, which is the combination of osteopenia and sarcopenia, in patients with colorectal liver metastases (CRLM) after hepatic resection.

Methods: One hundred and eighteen patients were analyzed retrospectively. Osteopenia was evaluated with computed tomographic measurement of pixel density in the midvertebral core of the 11th thoracic vertebra. Sarcopenia was evaluated with psoas muscle areas at the third lumbar vertebra. Osteosarcopenia was defined as the concomitant occurrence of osteopenia and sarcopenia.

Results: Osteosarcopenia was identified in 38 (32%) of the patients. In univariate analysis, the overall survival was significantly worse in patients with lymph node metastases (P = .01), extrahepatic lesion (P = .01), sarcopenia (P = .02), osteosarcopenia (P < .01), Glasgow Prognostic Score (GPS) 1 or 2 (P = .05), and curability R 1 or 2 (P = .04). In multivariate analysis, lymph node metastases (P < .01), osteosarcopenia (P < .01), and GPS 1 or 2 (P = .03) were independent and significant predictors of the overall survival. In patients with osteosarcopenia, there were more women than men and body mass index was lower compared to patients without osteosarcopenia.

Conclusion: Osteosarcopenia was the strong predictor for outcomes in patients who underwent liver resection for CRLM.

Keywords: colorectal liver metastases; liver resection; osteopenia; osteosarcopenia; sarcopenia.

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Conflict of interest statement

Conflict of Interest: The authors have no conflicts of interest and funding to declare.

Figures

FIGURE 1
FIGURE 1
(A) Measurement of bone mineral density (BMD) on trabecular bone with calculation of the average pixel density within a circle in midvertebral core at 11th thoracic vertebral level. (B) Kaplan‐Meier curve for overall survival after hepatic resection for colorectal liver metastases
FIGURE 2
FIGURE 2
(A) Measurement of psoas muscle mass are (PMA) at third lumbar vertebral level by radii of the major axes (continuous line) × radii of the minor axes (dotted line) × π. (B) Kaplan‐Meier curve for overall survival after hepatic resection for colorectal liver metastases
FIGURE 3
FIGURE 3
Kaplan‐Meier curve for overall survival after hepatic resection for colorectal liver metastases among (A) all patients, (B) women, and (C) men
FIGURE 4
FIGURE 4
Kaplan‐Meier curve for overall survival after hepatic resection for colorectal liver metastases in (A) patients with osteopenia alone (B) patients with sarcopenia alone compared to patients with osteosarcopenia
See this image and copyright information in PMC

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