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Editorial
. 2021 Jun 1;5(6):e579.
doi: 10.1097/HS9.0000000000000579. eCollection 2021 Jun.

The Premalignant Ancestor Cell of t(14;18)+ Lymphoma

Gabriel Brisou  1   2 , Bertrand Nadel  2 , Sandrine Roulland  2
Affiliations
Editorial

The Premalignant Ancestor Cell of t(14;18)+ Lymphoma

Gabriel Brisou et al. Hemasphere. .
No abstract available

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Figures

Figure 1.
Figure 1.
The current model of FL development. Follicular lymphoma biological complexity is depicted as resulting from a multihit pathway escalating along B cell differentiation stages over years/decades. Several premalignant intermediates have been identified or inferred as “precursors” or “CPC,” each of which could be at the origin of relapses. Characterizing such different CPC flavors (molecular/phenotypic/functional) is a current major challenge in the field. The arrows depict the supposed trajectory of follicular lymphoma precursor cells along the normal B cell differentiation path. BM = bone marrow; CPC = committed precursor clones; GC = germinal center; FL = follicular lymphoma; FLLC = follicular lymphoma like cells; ISFN = in situ follicular neoplasia; LN = lymph node; tFL = transformed follicular lymphoma.
Figure 2.
Figure 2.
FL malignant progression is characterized by a progressive desynchronization of a highly coordinated transcriptional program. Dendrograms represent gene correlation computed on single cell quantitative PCR data obtained from normal GC B cells (TOP) and FL cells (DOWN) in human and in a mouse model mimicking loss of Kmt2d and BCL2 overexpression (Kmt2d− BCL2+). The hierarchical clustering is based on gene evolution along the θ GC pseudotime, inferred from the data of thousands of single GC B cells, that model the GC cycle, allowing the identification of clusters of correlated and co-evolving genes characterizing the normal GC reaction; dashed lines at bottom of dendrograms obtained from normal GC B cells demarcate clusters of co-evolving genes during GC reaction.
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