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Randomized Controlled Trial
. 2021 Sep 1;181(9):1237-1239.
doi: 10.1001/jamainternmed.2021.1184.

Use of High-Sensitivity Cardiac Troponin in Patients With Kidney Impairment: A Randomized Clinical Trial

Peter J Gallacher  1 , Eve Miller-Hodges  1   2 , Anoop S V Shah  1   3 , Atul Anand  1 , Neeraj Dhaun  1   2 , Nicholas L Mills  1   4 ; High-STEACS Investigators
Collaborators, Affiliations
Randomized Controlled Trial

Use of High-Sensitivity Cardiac Troponin in Patients With Kidney Impairment: A Randomized Clinical Trial

Peter J Gallacher et al. JAMA Intern Med. .

Abstract

This randomized clinical trial examines the use of high-sensitivity cardiac troponin testing for patients with kidney impairment.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Gallagher reported research support from the Mason Medical Research Foundation and the British Heart Foundation (BHF). Dr Miller-Hodges reported grants from Wellcome Trust during the conduct of the study. Dr Shah reported other from speaker fees from Abbott Diagnostics during the conduct of the study. Dr Mills reported grants from Abbott Diagnostics, Siemens Healthineers, and the BHF as well as personal fees from Abbott Diagnostics, Siemens Healthineers, Roche Diagnostics, and LumiraDx outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Myocardial Injury and Myocardial Infarction (MI) in Patients With Kidney Impairment
A, Number of patients with high-sensitivity cardiac troponin concentrations above and below the sex-specific 99th percentile across the entire study population (n = 46 927) according to estimated glomerular filtration rate (eGFR). B, Frequency of adjudicated diagnoses in patients with high-sensitivity cardiac troponin concentrations above the sex-specific 99th percentile (n = 10 111), according to eGFR.
See this image and copyright information in PMC

Comment in

References

    1. Thygesen K, Alpert JS, Jaffe AS, et al. ; Executive Group on behalf of the Joint European Society of Cardiology (ESC)/American College of Cardiology (ACC)/American Heart Association (AHA)/World Heart Federation (WHF) Task Force for the Universal Definition of Myocardial Infarction . Fourth universal definition of myocardial infarction (2018). J Am Coll Cardiol. 2018;72(18):2231-2264. doi:10.1016/j.jacc.2018.08.1038 - DOI - PubMed
    1. deFilippi CR, Herzog CA. Interpreting cardiac biomarkers in the setting of chronic kidney disease. Clin Chem. 2017;63(1):59-65. doi:10.1373/clinchem.2016.254748 - DOI - PubMed
    1. Shah ASV, Anand A, Strachan FE, et al. ; High-STEACS Investigators . High-sensitivity troponin in the evaluation of patients with suspected acute coronary syndrome: a stepped-wedge, cluster-randomised controlled trial. Lancet. 2018;392(10151):919-928. doi:10.1016/S0140-6736(18)31923-8 - DOI - PMC - PubMed
    1. Miller-Hodges E, Anand A, Shah ASV, et al. . High-sensitivity cardiac troponin and the risk stratification of patients with renal impairment presenting with suspected acute coronary syndrome. Circulation. 2018;137(5):425-435. doi:10.1161/CIRCULATIONAHA.117.030320 - DOI - PMC - PubMed
    1. Twerenbold R, Badertscher P, Boeddinghaus J, et al. . 0/1-Hour triage algorithm for myocardial infarction in patients with renal dysfunction. Circulation. 2018;137(5):436-451. doi:10.1161/CIRCULATIONAHA.117.028901 - DOI - PMC - PubMed

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