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. 2021 Sep;47(9):1021-1023.
doi: 10.1007/s00134-021-06439-6. Epub 2021 Jun 7.

Neurological complications of COVID-19

Virginia F J Newcombe  1 , Neha S Dangayach  2 , Romain Sonneville  3   4
Affiliations

Neurological complications of COVID-19

Virginia F J Newcombe et al. Intensive Care Med. 2021 Sep.
No abstract available

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Schematic of potential mechanisms and complications of NeuroCOVID. Direct infection and replication via transsynaptic spread of peripheral and cranial nerves (e.g. vagal or olfactory nerves) or blood–brain barrier dysfunction may lead to the clinical syndromes of encephalitis, myelitis and meningitis (S1). However, given that detection of SARS-CoV-2 in CSF via Polymerase Chain Reaction (PCR) or intrathecal antibodies is rare, direct neuroinvasion is likely to account for only a minority of cases (S2). Neuroinflammation with entry to the CNS of cytokines is thought to occur (S1). Autoimmune neurological syndromes including acute disseminated encephalomyelitis, myelitis, and Guillain–Barre Syndrome have also been reported (S3). Endotheliopathy and/or hypercoagulability have been implicated in the pathogenesis of stroke secondary to COVID019 (S4, S5). PTSD post traumatic stress disorder. Image created with BioRender.com. References for the figure may be found in the Supplementary material
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References

    1. Zubair AS, McAlpine LS, Gardin T, Farhadian S, Kuruvilla DE, Spudich S. Neuropathogenesis and neurologic manifestations of the coronaviruses in the age of coronavirus disease 2019: a review. JAMA Neurol. 2020;77:1018–1027. doi: 10.1001/jamaneurol.2020.2065. - DOI - PMC - PubMed
    1. Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, et al. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol. 2020;77:683–690. doi: 10.1001/jamaneurol.2020.1127. - DOI - PMC - PubMed
    1. Varatharaj A, Thomas N, Ellul MA, Davies NWS, Pollak TA, Tenorio EL, Sultan M, Easton A, Breen G, Zandi M, et al. Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study. Lancet Psychiatry. 2020;7:875–882. doi: 10.1016/S2215-0366(20)30287-X. - DOI - PMC - PubMed
    1. Meppiel E, Peiffer-Smadja N, Maury A, Bekri I, Delorme C, Desestret V, Gorza L, Hautecloque-Raysz G, Landre S, Lannuzel A, et al. Neurologic manifestations associated with COVID-19: a multicentre registry. Clin Microbiol Infect. 2021;27:458–466. doi: 10.1016/j.cmi.2020.11.005. - DOI - PMC - PubMed
    1. Nannoni S, de Groot R, Bell S, Markus HS. Stroke in COVID-19: a systematic review and meta-analysis. Int J Stroke. 2021;16:137–149. doi: 10.1177/1747493020972922. - DOI - PMC - PubMed

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