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. 2021 Dec;40(12):2651-2656.
doi: 10.1007/s10096-021-04287-2. Epub 2021 Jun 7.

The prevalence and functional characteristics of CrpP-like in Pseudomonas aeruginosa isolates from China

Ye Xu  1 , Ying Zhang  2 , Xiangkuo Zheng  1 , Kaihang Yu  2 , Yao Sun  1 , Wenli Liao  1 , Huaiyu Jia  1 , Chunquan Xu  1 , Tieli Zhou  3 , Mo Shen  4
Affiliations

The prevalence and functional characteristics of CrpP-like in Pseudomonas aeruginosa isolates from China

Ye Xu et al. Eur J Clin Microbiol Infect Dis. 2021 Dec.

Abstract

Modifying enzyme-CrpP and its variants reduced the MICs of fluoroquinolones in Pseudomonas aeruginosa. This study investigated the dissemination and functional characteristics of CrpP-like in P. aeruginosa from China. The positive rate of crpP-like genes in 228 P. aeruginosa was 25.4% (58/228), and 6 new crpP-like genes were determined. Transformation experiments showed that CrpP-like had a low effect on CIP and LEV susceptibility. The genetic of crpP-positive was diverse. Furthermore, the mean expression level of crpP was no statistical difference between fluoroquinolone-susceptible and -resistant group (P > 0.05). CrpP-like may not play a significant role in fluoroquinolone resistance in P. aeruginosa.

Keywords: CrpP-like; Fluoroquinolone; Pseudomonas aeruginosa; Resistance.

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