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. 2021 Jul 16;65(8):e0027721.
doi: 10.1128/AAC.00277-21. Epub 2021 Jul 16.

Diversity of Sequence Types and Impact of Fitness Cost among Carbapenem-Resistant Acinetobacter baumannii Isolates from Tripoli, Libya

Antoine G Abou Fayad #  1   2   3 , Louis-Patrick Haraoui #  4 , Ahmad Sleiman  1   2   3 , Mohamad Jaafar  1   2   3 , Abdulaziz Zorgani  5 , Ghassan M Matar  1   2   3 , Paul G Higgins  6   7
Affiliations

Diversity of Sequence Types and Impact of Fitness Cost among Carbapenem-Resistant Acinetobacter baumannii Isolates from Tripoli, Libya

Antoine G Abou Fayad et al. Antimicrob Agents Chemother. .

Abstract

We investigated the molecular epidemiology of 21 carbapenem-resistant Acinetobacter baumannii isolates from Libya and assessed their relative fitness. Core genome multilocus sequence typing (MLST) revealed five interhospital transmission clusters. Three clusters were associated with the international clones (IC) IC1, IC2, and IC7. Carbapenem-resistance was associated with blaOXA-23, blaGES-11, or blaNDM-1. Compared to that of A. baumannii DSM 30008, the doubling time was similar over 10 h, but after 16 h, half the isolates grew to higher densities, suggesting a fitness advantage.

Keywords: Acinetobacter baumannii; antimicrobial resistance; carbapenems; fitness cost.

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Figures

FIG 1
FIG 1
cgMLST of the 23 A. baumannii isolates.
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