Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Aug 15:357:577598.
doi: 10.1016/j.jneuroim.2021.577598. Epub 2021 May 1.

Epidemiology of neuronal surface antibody-mediated autoimmune encephalitis and antibody-based diagnostics

Luigi Zuliani  1 , Sabrina Marangoni  2 , Piera De Gaspari  3 , Irene Rosellini  4 , Margherita Nosadini  5 , Joanne M Fleming  6 , Valentina De Riva  7 , Elisabetta Galloni  7 , Francesco Perini  7 , Anna Chiara Frigo  8 , Stefano Sartori  5 , Marco Zoccarato  9 , Bruno Giometto  2
Affiliations
Free article

Epidemiology of neuronal surface antibody-mediated autoimmune encephalitis and antibody-based diagnostics

Luigi Zuliani et al. J Neuroimmunol. .
Free article

Abstract

Epidemiologic data on neuronal surface antibody (NSAb)-associated autoimmune encephalitides (NSAE) are scarce and heterogeneous. We review our 13-year-long biobank-data collection and provide the incidence of NSAE in two Italian provinces (approx. Population of 1,400,000) over a 5-year period (July 2013-June 2018). NSAbs were diagnosed in 75 out of 1179 tested patients (6.4%). The most common NSAbs were anti-LGI1 (30 cases), followed by NMDAR (24). Eleven cases of NSAE were diagnosed in Treviso and Trento provinces with an estimated incidence of 1.54 per 1,000,000 population (LGI1-encephalitis 0.84; C.I. 0.38-1.88). LGI1-E is the most frequent NSAE among adults.

Keywords: Autoimmune encephalitis; Epidemiology; Incidence; LGI1; NMDAR; Neuronal surface antibodies.

PubMed Disclaimer