doi: 10.1016/0014-2999(88)90675-9.
The oxytocin antagonist d(CH2)5Tyr(Me)-Orn8-vasotocin inhibits male copulatory behaviour in rats
Affiliations
- PMID: 3409963
- DOI: 10.1016/0014-2999(88)90675-9
Item in Clipboard
The oxytocin antagonist d(CH2)5Tyr(Me)-Orn8-vasotocin inhibits male copulatory behaviour in rats
Eur J Pharmacol.
.
Abstract
The effect of an intracerebroventricular (i.c.v.) injection of the oxytocin antagonist, d(CH2)5Tyr(Me)-Orn8-vasotocin, on the copulatory behaviour of vigorous male rats in the presence of females in estrus was studied. The peptide (2.5, 25 and 50 ng, 15 min before mating tests) decreased the number of mounts and intromissions, and abolished ejaculation almost completely at all doses tested. The peptide failed to significantly influence motor activity at the doses used. The results support the hypothesis that central oxytocin plays a physiological role in the expression of copulatory behaviour.
Similar articles
-
Apomorphine stimulation of male copulatory behavior is prevented by the oxytocin antagonist d(CH2)5 Tyr(Me)-Orn8-vasotocin in rats.Pharmacol Biochem Behav. 1989 May;33(1):81-3. doi: 10.1016/0091-3057(89)90433-4. Pharmacol Biochem Behav. 1989. PMID: 2780793
-
d(CH2)5Tyr(Me)-[Orn8]vasotocin, a potent oxytocin antagonist, antagonizes penile erection and yawning induced by oxytocin and apomorphine, but not by ACTH-(1-24).Eur J Pharmacol. 1987 Feb 10;134(2):221-4. doi: 10.1016/0014-2999(87)90168-3. Eur J Pharmacol. 1987. PMID: 3032653
-
Oxytocin enhances, and oxytocin antagonism decreases, sexual receptivity in intact female rats.Neuropeptides. 1994 Oct;27(4):245-50. doi: 10.1016/0143-4179(94)90005-1. Neuropeptides. 1994. PMID: 7808597
-
The oxytocin antagonist d(CH2)5Tyr(Me)2-Orn8-vasotocin reduces non-contact penile erections in male rats.Neurosci Lett. 1999 Apr 23;265(3):171-4. doi: 10.1016/s0304-3940(99)00236-0. Neurosci Lett. 1999. PMID: 10327158
-
Evidence that apomorphine induces penile erection and yawning by releasing oxytocin in the central nervous system.Eur J Pharmacol. 1989 May 30;164(3):565-70. doi: 10.1016/0014-2999(89)90265-3. Eur J Pharmacol. 1989. PMID: 2767126
Cited by
-
Inhibition of ejaculation by the non-peptide oxytocin receptor antagonist GSK557296: a multi-level site of action.Br J Pharmacol. 2013 Aug;169(7):1477-85. doi: 10.1111/bph.12198. Br J Pharmacol. 2013. PMID: 23530818 Free PMC article.
-
Sexual experience increases oxytocin receptor gene expression and protein in the medial preoptic area of the male rat.Psychoneuroendocrinology. 2013 Sep;38(9):1688-97. doi: 10.1016/j.psyneuen.2013.02.002. Epub 2013 Mar 7. Psychoneuroendocrinology. 2013. PMID: 23474276 Free PMC article.
-
The output of the hippocampus is inhibited during social behavior in the male rat.Exp Brain Res. 1996 Sep;111(1):35-40. doi: 10.1007/BF00229553. Exp Brain Res. 1996. PMID: 8891634
-
Oxytocin in the medial preoptic area facilitates male sexual behavior in the rat.Horm Behav. 2011 Apr;59(4):435-43. doi: 10.1016/j.yhbeh.2010.12.012. Epub 2010 Dec 31. Horm Behav. 2011. PMID: 21195714 Free PMC article.
-
Somatic genital reflexes in rats with a nod to humans: anatomy, physiology, and the role of the social neuropeptides.Horm Behav. 2011 May;59(5):656-65. doi: 10.1016/j.yhbeh.2011.02.006. Epub 2011 Feb 19. Horm Behav. 2011. PMID: 21338605 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
