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. 1988 May 10;149(3):393-5.
doi: 10.1016/0014-2999(88)90676-0.

Specific motor effects of capsaicin on human jejunum

C A Maggi  1 , R Patacchini, P Santicioli, S Giuliani, D Turini, G Barbanti, P Beneforti, D Misuri, A Meli
Affiliations

Specific motor effects of capsaicin on human jejunum

C A Maggi et al. Eur J Pharmacol. .

Abstract

Capsaicin (1 microM) produced a biphasic effect on the motility of longitudinal muscle strips from human jejunum e.g. an initial inhibitory effect on nerve-mediated contractions followed by a delayed increase in motility. Neither effect was observed upon a second application of the drug, indicating desensitization, a proposed marker of the action of capsaicin on sensory nerves. Both substance P and neurokinin A produced a contraction of isolated human jejunum, while calcitonin gene-related peptide had a small and inconsistent inhibitory effect.

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