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Comment
. 2021 Jun 8:10:e69863.
doi: 10.7554/eLife.69863.

Working together

Regan Odongo  1 , Tunahan Çakır  1
Affiliations
Comment

Working together

Regan Odongo et al. Elife. .

Abstract

Heart attacks have a ripple effect on how other organs exchange biomolecules that help the heart respond to injury.

Keywords: Heart attack; computational biology; medicine; metabolically active tissues; mouse; multi-tissue; network analysis; systems biology; whole-body modelling.

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Conflict of interest statement

RO, TÇ No competing interests declared

Figures

Figure 1.
Figure 1.. Heart attacks cause molecular changes in multiple tissues.
Acute heart attacks were induced in mice by blocking some of the arteries that supply blood to the heart, resulting in an irregular heartbeat. Samples were then collected from the heart, skeletal muscle, liver and adipose, or 'fat', tissues of these mice (red heart) and control animals that had not undergone a heart attack (green heart). RNA sequencing revealed that the heart attack altered genes expressed in all four of these tissues. Further computational simulations suggest that these genetic changes alter the production of metabolites that are then taken up by the other tissues (represented by arrows).
See this image and copyright information in PMC

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