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. 2021 Oct;195(1):137-140.
doi: 10.1111/bjh.17630. Epub 2021 Jun 7.

Changes in intensive care unit admission rates, organ support, and mortality in patients with acute myeloid leukaemia over a 12-year period: a Danish nationwide cohort study

Cecilie V Maeng  1 , Lene Sofie G Østgård  1   2   3 , Christian F Christiansen  3 , Kathleen D Liu  4
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Changes in intensive care unit admission rates, organ support, and mortality in patients with acute myeloid leukaemia over a 12-year period: a Danish nationwide cohort study

Cecilie V Maeng et al. Br J Haematol. 2021 Oct.

Abstract

Changes in acute myeloid leukaemia (AML) treatment may affect requirement for admission to and treatments in intensive care units (ICUs). We evaluated trends in ICU admission, use of organ support, and 1-year mortality in Danish AML patients. Of 1417 AML patients diagnosed 2005-2016, 28.0% (n=397) were ICU-admitted within 3 years, with no major change in admission rate during the 12-year period. Use of mechanical ventilation and dialysis decreased (66.7% to 40.6%), while use of non-invasive ventilation increased (20.0% to 50.0%). Concurrently, 1-year mortality declined among all patients (36.0% in 2005 to 28.8% in 2016) and ICU-admitted patients (80.0% to 65.6%).

Keywords: acute myeloid leukaemia; intensive care; organ support; population-based; survival.

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Figures

Figure I.
Figure I.
Changes in 1-mortality (A), use of mechanical ventilation (B) and use of dialysis and vasopressor (C). The graphs illustrate rates of either 1-year mortality or treatment and 95% confidence interval in the individual year. The dotted lines show a linear regression.
See this image and copyright information in PMC

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