The statistical risk of diagnosing coincidental acquired hemophilia A following anti-SARS-CoV-2 vaccination

Micol G Cittone^{1

2}, Raphael Battegay³, Adalgisa Condoluci^{1

2}, Lodovico Terzi di Bergamo², Eliana Fernandes¹, Elena Galfetti¹, Roberta Noseda⁴, Anne Leuppi-Taegtmeyer⁵, Beatrice Drexler³, Alessandro Ceschi^{4

6}, Dimitrios A Tsakiris³, Christoph T Berger^{7

8}, Genevieve Favre⁹, Thomas Martin¹⁰, Wolfgang Korte¹⁰, Lukas Graf¹⁰, Maria Martinez¹¹, Bernhard Gerber^{1

12}

Affiliations

¹ Clinic of Hematology, Oncology Institute of Southern Switzerland, EOC, Bellinzona, Switzerland.
² Institute of Oncology Research (IOR), Bellinzona, Switzerland.
³ Division of Hematology, University Hospital Basel, Basel, Switzerland.
⁴ Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, EOC, Lugano, Switzerland.
⁵ Regional Pharmacovigilance Centre, Department of Clinical Pharmacology and Toxicology, University Hospital Basel, University of Basel, Basel, Switzerland.
⁶ Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
⁷ Translational Immunology, Department of Biomedicine, University of Basel, Basel, Switzerland.
⁸ Clinical Immunology, Medical Outpatient Unit, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland.
⁹ Division of Hematology, Cantonal Hospital Liestal, Liestal, Switzerland.
¹⁰ Hemophilia and Hemostasis Center, Centre for Laboratory Medicine, St. Gallen, Switzerland.
¹¹ Department of Diagnostic Hematology, University of Basel, Basel, Switzerland.
¹² University of Zurich, Zurich, Switzerland.

PMID: 34101973
PMCID: PMC9771119
DOI: 10.1111/jth.15421

Comment

The statistical risk of diagnosing coincidental acquired hemophilia A following anti-SARS-CoV-2 vaccination

Micol G Cittone et al. J Thromb Haemost. 2021 Sep.

. 2021 Sep;19(9):2360-2362.

doi: 10.1111/jth.15421. Epub 2021 Jun 26.

Authors

Affiliations

¹ Clinic of Hematology, Oncology Institute of Southern Switzerland, EOC, Bellinzona, Switzerland.
² Institute of Oncology Research (IOR), Bellinzona, Switzerland.
³ Division of Hematology, University Hospital Basel, Basel, Switzerland.
⁴ Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Sciences of Southern Switzerland, EOC, Lugano, Switzerland.
⁵ Regional Pharmacovigilance Centre, Department of Clinical Pharmacology and Toxicology, University Hospital Basel, University of Basel, Basel, Switzerland.
⁶ Faculty of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland.
⁷ Translational Immunology, Department of Biomedicine, University of Basel, Basel, Switzerland.
⁸ Clinical Immunology, Medical Outpatient Unit, Department of Internal Medicine, University Hospital Basel, Basel, Switzerland.
⁹ Division of Hematology, Cantonal Hospital Liestal, Liestal, Switzerland.
¹⁰ Hemophilia and Hemostasis Center, Centre for Laboratory Medicine, St. Gallen, Switzerland.
¹¹ Department of Diagnostic Hematology, University of Basel, Basel, Switzerland.
¹² University of Zurich, Zurich, Switzerland.

PMID: 34101973
PMCID: PMC9771119
DOI: 10.1111/jth.15421

No abstract available

Keywords: AHA; COVID-19; SARS-CoV-2 vaccine; acquired hemophilia A; hemostasis.

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Comment in

Autoimmunity after Coronavirus Disease 2019 (COVID-19) Vaccine: A Case of Acquired Hemophilia A.
Farley S, Ousley R, Van Wagoner N, Bril F. Farley S, et al. Thromb Haemost. 2021 Dec;121(12):1674-1676. doi: 10.1055/a-1579-5396. Epub 2021 Sep 16. Thromb Haemost. 2021. PMID: 34352911 No abstract available.

Comment on

A case report of acquired hemophilia following COVID-19 vaccine.
Radwi M, Farsi S. Radwi M, et al. J Thromb Haemost. 2021 Jun;19(6):1515-1518. doi: 10.1111/jth.15291. Epub 2021 May 10. J Thromb Haemost. 2021. PMID: 33783953 Free PMC article.

References

1. Radwi M., Farsi S.A. Case report of acquired haemophilia following COVID‐19 vaccine. J Thromb Haemost. 2021;19(6):1515–1518. - PMC - PubMed
1. https://www.covid19.admin.ch/en/epidemiologic/vacc‐doses, online open Accessed April 20, 2021.
1. https://www.bfs.admin.ch/bfs/en/home/statistics/population/effectif‐chan..., online open. Accessed April 20, 2021.
1. Tiede A., Wahler S. The rising incidence of acquired haemophilia A in Germany. Haemophilia. 2020 doi: 10.1111/hae.14149. - DOI - PubMed
1. Collins P.W., Hirsch S., Baglin T.P., et al. Acquired hemophilia A in the United Kingdom: a 2‐year national surveillance study by the United Kingdom haemophilia centre doctors’ organisation. Blood. 2007;109(5):1870–1877. - PubMed

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The statistical risk of diagnosing coincidental acquired hemophilia A following anti-SARS-CoV-2 vaccination

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The statistical risk of diagnosing coincidental acquired hemophilia A following anti-SARS-CoV-2 vaccination

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