Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Sep;9(7):787-796.
doi: 10.1002/ueg2.12103. Epub 2021 Jun 8.

What gastroenterologists should know about SARS-CoV 2 vaccine: World Endoscopy Organization perspective

Marco Spadaccini  1   2 , Lorenzo Canziani  2   3 , Alessio Aghemo  2   4 , Ana Lleo  2   4 , Roberta Maselli  1   2 , Andrea Anderloni  2 , Silvia Carrara  2 , Alessandro Fugazza  2 , Gaia Pellegatta  2 , Piera Alessia Galtieri  2 , Cesare Hassan  5 , David Greenwald  6 , Mark Pochapin  7 , Michael Wallace  8 , Prateek Sharma  9 , Thomas Roesch  10 , Pradeep Bhandari  11 , Fabian Emura  12 , Gottumukkala S Raju  13 , Alessandro Repici  1   2
Affiliations
Review

What gastroenterologists should know about SARS-CoV 2 vaccine: World Endoscopy Organization perspective

Marco Spadaccini et al. United European Gastroenterol J. 2021 Sep.

Abstract

Background: The novel Coronavirus (SARS-CoV-2) has caused almost 2 million deaths worldwide. Both Food and Drug Administration and European Medicines Agency have recently approved the first COVID-19 vaccines, and a few more are going to be approved soon.

Methods: Several different approaches have been used to stimulate the immune system in mounting a humoral response. As more traditional approaches are under investigation (inactivated virus vaccines, protein subunit vaccines, recombinant virus vaccines), more recent and innovative strategies have been tried (non-replicating viral vector vaccines, RNA based vaccines, DNA based vaccines).

Results: Since vaccinations campaigns started in December 2020 in both the US and Europe, gastroenterologists will be one of the main sources of information regarding SARS-CoV 2 vaccination for patients in their practice, including vulnerable patients such as those with Inflammatory Bowel Disease (IBD), patients with chronic liver disease, and GI cancer patients.

Conclusions: Thus, we must ourselves be well educated and updated in order to provide unambiguous counseling to these categories of vulnerable patients. In this commentary, we aim to provide a comprehensive review of both approved COVID-19 vaccines and the ones still under development, and explore potential risks, benefits and prioritization of vaccination.

Keywords: Coronavirus; endoscopy; prevention; public health; vaccine.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

FIGURE 1
FIGURE 1
COVID‐19 vaccines mechanisms
FIGURE 2
FIGURE 2
High priority patients. CH: care home. HCW: health care workers. *immunocompromised, multiple comorbidities, chronic lung disease, diabetes, cardiovascular disease and severe obesity
See this image and copyright information in PMC

References

    1. World Health Organization . Pneumonia of unknown caused China. https://www.who.int/csr/don/05-january-2020-pneumoniaof-unkown-cause-chi.... 14 February 2020.
    1. COVID‐19 CORONAVIRUS PANDEMIC . Last updated: January 16, 2021, 13:03 GMT. https://www.worldometers.info/coronavirus/.
    1. Legido‐Quigley H, Asgari N, Teo YY, Leung GM, Oshitani H, Fukuda K , et al. Are high‐performing health systems resilient against the COVID‐19 epidemic? Lancet. 2020;395:848–50. - PMC - PubMed
    1. Arun TK. Coronavirus: is there an alternative to lockdowns? Economic Times. WHO. 2020. Coronavirus Disease (COVID‐19) Advice for the Public. Geneva, Switzerland; 2020. Available from: https://www.who.int/emergencies/diseases/novel‐coronavirus‐2019/advice‐f.... Updated WHO Recommendations for International Traffic in Relation to the COVID‐19 Outbreak. Geneva, Switzerland; 2020 [Feb 29th 2020]. Available from: https://www.who.int/newsroom/articles-detail/updated-who-recommendations...
    1. Canziani LM, Trovati S, Brunetta E, Testa A, De Santis M, Bombardieri E, et al. Humanitas and Gavazzeni/Castelli COVID‐19 Task Forces. Interleukin‐6 receptor blocking with intravenous tocilizumab in COVID‐19 severe acute respiratory distress syndrome: a retrospective case‐control survival analysis of 128 patients. J Autoimmun. 2020;114:102511. 10.1016/j.jaut.2020.102511. Epub 2020 Jul 8. PMID: 32713677; PMCID: PMC7342030 - DOI - PMC - PubMed

MeSH terms