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Comment
. 2021 Aug:204:13-15.
doi: 10.1016/j.thromres.2021.05.016. Epub 2021 May 29.

Low admission protein C levels are a risk factor for disease worsening and mortality in hospitalized patients with COVID-19

Tara M Stanne  1 , Annie Pedersen  2 , Magnus Gisslén  3 , Christina Jern  2
Affiliations
Comment

Low admission protein C levels are a risk factor for disease worsening and mortality in hospitalized patients with COVID-19

Tara M Stanne et al. Thromb Res. 2021 Aug.
No abstract available

Keywords: Anticoagulant; COVID-19; Fibrinolysis; Protein C; SARS-CoV-2.

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Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:

T.M. Stanne, A. Pedersen and C. Jern have nothing to disclose. M Gisslen reports personal fees from Amgen, Biogen, Gilead, GSK/ViiV, Novocure and Novo Nordic all of which are outside the scope of the submitted work.

Figures

Fig. 1
Fig. 1
Plasma levels of hemostatic proteins and 28-day disease worsening in hospitalized COVID-19 patients. Odds ratio (OR) and 95% confidence intervals for disease worsening from (A) univariate ordinal logistic regression and (B) multivariate ordinal logistic regression (adjusted for clinical variables and admission laboratory measures; see Table 1). (C): Receiver operating characteristic curves showing the predictive value of protein C over clinical variables and laboratory parameters.
See this image and copyright information in PMC

Comment on

References

    1. Gerotziafas G.T., Sergentanis T.N., Voiriot G., Lassel L., Papageorgiou C., Elabbadi A., Turpin M., Vandreden P., Papageorgiou L., Psaltopoulou T., Terpos E., Dimopoulos M.A., Parrot A., Cadranel J., Pialoux G., Fartoukh M., Elalamy I. Derivation and validation of a predictive score for disease worsening in patients with COVID-19. Thromb. Haemost. 2020;120:1680–1690. doi: 10.1055/s-0040-1716544. - DOI - PMC - PubMed
    1. Levi M., Thachil J. Coronavirus disease 2019 coagulopathy: disseminated intravascular coagulation and thrombotic microangiopathy—either, neither, or both. Semin. Thromb. Hemost. 2020;46:781–784. doi: 10.1055/s-0040-1712156. - DOI - PMC - PubMed
    1. Filbin MR, Mehta A, Schneider AM, Kays KR, Guess JR, Gentili M, Fenyves BG, Charland NC, Gonye ALK, Gushterova I, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilly BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN, Rojas-Lopez M, Russo BC, et al. Plasma proteomics reveals tissue-specific cell death and mediators of cell-cell interactions in severe COVID-19 patients. bioRxiv. 2020;2020.11.02.365536. doi: 10.1101/2020.11.02.365536. Preprint. - DOI
    1. Mazzeffi M., Chow J.H., Amoroso A., Tanaka K. Revisiting the protein C pathway: an opportunity for adjunctive intervention in COVID-19? Anesth. Analg. 2020;131:690–693. doi: 10.1213/ANE.0000000000005059. - DOI - PMC - PubMed
    1. Faust S.N., Levin M., Harrison O.B., Goldin R.D., Lockhart M.S., Kondaveeti S., Laszik Z., Esmon C.T., Heyderman R.S. Dysfunction of endothelial protein C activation in severe meningococcal sepsis. N. Engl. J. Med. 2001;345:408–416. doi: 10.1056/NEJM200108093450603. - DOI - PubMed