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. 2021 May;23(2):281-284.
doi: 10.5853/jos.2020.04784. Epub 2021 May 31.

7T Magnetic Resonance Imaging Quantification of Brain Glutamate in Acute Ischaemic Stroke

John-Paul Nicolo  1   2   3   4 , Bradford Moffat  5 , David K Wright  4 , Benjamin Sinclair  4 , Andrew Neal  1   2   3   4 , Elaine Lui  6   7 , Patricia Desmond  6   7 , Rebecca Glarin  6   7 , Kathryn A Davis  8 , Ravinder Reddy  9 , Bernard Yan  1   3 , Terence J O'Brien  1   2   3   4 , Patrick Kwan  1   2   3   4
Affiliations

7T Magnetic Resonance Imaging Quantification of Brain Glutamate in Acute Ischaemic Stroke

John-Paul Nicolo et al. J Stroke. 2021 May.
No abstract available

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Figures

Figure 1.
Figure 1.
Diffusion weighted imaging and chemical exchange saturation transfer (CEST) images from patient 8 (A) and patient 11 (B) demonstrating regionally increased and decreased glutamate weighted chemical exchange saturation transfer (GluCEST) contrast ipsilateral to the infarction. The asymmetry in GluCEST contrast in regions distant to the infarction may be due to brain positioning asymmetry.
See this image and copyright information in PMC

References

    1. Nicolo JP, O’Brien TJ, Kwan P. Role of cerebral glutamate in post-stroke epileptogenesis. Neuroimage Clin. 2019;24:102069. - PMC - PubMed
    1. Cai K, Haris M, Singh A, Kogan F, Greenberg JH, Hariharan H, et al. Magnetic resonance imaging of glutamate. Nat Med. 2012;18:302–306. - PMC - PubMed
    1. Neal A, Moffat BA, Stein JM, Nanga RPR, Desmond P, Shinohara RT, et al. Glutamate weighted imaging contrast in gliomas with 7 Tesla magnetic resonance imaging. Neuroimage Clin. 2019;22:101694. - PMC - PubMed
    1. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med. 1993;30:672–679. - PubMed
    1. Bivard A, Yassi N, Krishnamurthy V, Lin L, Levi C, Spratt NJ, et al. A comprehensive analysis of metabolic changes in the salvaged penumbra. Neuroradiology. 2016;58:409–415. - PubMed

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