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. 2021 Sep;46(9):705-707.
doi: 10.1016/j.tibs.2021.05.008. Epub 2021 Jun 5.

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Alexis Verger  1 , Didier Monté  2 , Vincent Villeret  2
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Alexis Verger et al. Trends Biochem Sci. 2021 Sep.
Free article

Abstract

Cryo-electron microscopy has enabled unprecedented progress in the quest to reveal the structure of the whole transcription preinitiation complex. Four recent studies pave the way for a complete description of how transcription is initiated at near-atomic level.

Keywords: RNA polymerase II; cryo-EM; mediator; preinitiation complex; transcription.

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Conflict of interest statement

Declaration of Interests The authors declare no conflicts of interest.

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