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. 2021 May 31:14:581-589.
doi: 10.2147/CCID.S312198. eCollection 2021.

Immediate nor Delayed Type Hypersensitivity Plays a Role in Late Inflammatory Reactions After Hyaluronic Acid Filler Injections

Tom Decates #  1 , Jonathan Kadouch #  1 , Peter Velthuis  1 , Thomas Rustemeyer  2
Affiliations

Immediate nor Delayed Type Hypersensitivity Plays a Role in Late Inflammatory Reactions After Hyaluronic Acid Filler Injections

Tom Decates et al. Clin Cosmet Investig Dermatol. .

Abstract

Purpose: The exact etiology of late inflammatory reactions (LIRs) to hyaluronic acid (HA) fillers is currently unknown. Some argue that these result from a hypersensitivity reaction, although evidence to support this is very scarce. Most reports on such reactions are not substantiated by positive skin tests. The purpose of our study was to determine whether immediate or delayed type hypersensitivity reaction follows hyaluronic acid (HA) filler injections.

Patients and methods: Twelve patients were referred for general allergic screening (patch tests), as well as specific intradermal testing (injection of 0.1cc boluses) on the medial upper arm with a selection of several currently available hyaluronic acid (HA) fillers on the market. A positive allergic reaction was defined as erythema, firmness or swelling.

Results: During the 4 month follow-up, no reactions to any of the tested HA fillers were reported. No correlation was found between results from the general allergic screening and a history with LIRs to HA fillers.

Conclusion: The results suggest that neither type I nor type IV hypersensitivity plays a role in late inflammatory reactions (LIRs) to hyaluronic acid (HA) fillers.

Keywords: allergy; complications; cosmetic; cosmetic dermatology.

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Conflict of interest statement

Dr Jonathan Kadouch is a Consultant for Merz Aesthetics. All authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Oversight of the different etiological hypothesis for late inflammatory reactions (LIRs) to fillers.
Figure 2
Figure 2
Design of intradermal testing protocol.
None
See this image and copyright information in PMC

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