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Review
. 2021 Jun 1:13:139-152.
doi: 10.2147/OARRR.S282627. eCollection 2021.

Current and Emerging DMARDs for the Treatment of Rheumatoid Arthritis

Eduardo Mysler  1 , Mariana Caubet  1 , Ana Lizarraga  1
Affiliations
Review

Current and Emerging DMARDs for the Treatment of Rheumatoid Arthritis

Eduardo Mysler et al. Open Access Rheumatol. .

Abstract

Rheumatoid arthritis (RA) is the most prevalent form of inflammatory arthritis. It is a profoundly serious and severe disease that if it goes untreated could have severe consequences to the joints and health of the patient who carries this diagnosis. The treatment of RA has dramatically changed since the year 2000, with the discovery of the TNFis, then other biologics, and finally the JAKi. All these new medications with or without methotrexate in combination, tight control and treat to target have produced a revolution in the outcome of this disease. We reviewed and summarized the treatment options, and the most significant papers for each one of these new drugs. The reader could have a full picture with all the references of the recent publications. We also updated the biosimilar situation in RA, as well as the new drugs that will be coming to the market in the next 5 years.

Keywords: DMARDs; biosimilars; rheumatoid arthritis.

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Conflict of interest statement

Dr Eduardo Mysler reports grants, personal fees from Pfizer, Roche, grants from AbbVie, GSK, Aztra Zeneca, Sandoz, Lilly, Sanofi, grants from Novartis, BMS, grants from Janssen, Amgen, outside the submitted work. The authors report no other conflicts of interest in this work.

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References

    1. Smolen JS, Aletaha D, McInees LB. Rheumatoid arthritis. Lancet. 2016;388(10055):2023–2038. doi:10.1016/S0140-6736(16)30173-8 - DOI - PubMed
    1. Smolen JS, Landewé RBM, Bijlsma JWJ, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update. Ann Rheum Dis. 2020;79(6):685–699. doi:10.1136/annrheumdis-2019-216655 - DOI - PubMed
    1. Smolen JS, Breedveld FC, Burmester GR, et al. Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force. Ann Rheum Dis. 2016;75(1):3–15. doi:10.1136/annrheumdis-2015-207524 - DOI - PMC - PubMed
    1. Jasvinder AS, Kenneth GS, Louis Bridges JR, et al. 2015 American college of rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Care Res. 2016;68(1):1–25. doi:10.1002/acr.22783 - DOI - PubMed
    1. van Vollenhoven RF, Geborek P, Forslind K, et al. Conventional combination treatment versus biological treatment in methotrexate-refractory early rheumatoid arthritis: 2 years follow-up of the randomised, non-blinded, parallel-group Swefot trial. Lancet. 2012;379(9827):1712–1720. doi:10.1016/S0140-6736(12)60027-0 - DOI - PubMed