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Case Reports
. 2021 Mar 17:18:15.
eCollection 2021.

Canalicular adenoma of the hard palate: A rare case report

Milad Khodaei  1 , Masoomeh Amani  2 , Sina Mirinezhad  2 , Sona Rafieyan  3
Affiliations
Case Reports

Canalicular adenoma of the hard palate: A rare case report

Milad Khodaei et al. Dent Res J (Isfahan). .

Abstract

Canalicular adenoma (CA) is a rare, benign salivary gland tumor that has special tendency to occur in the upper lip. Buccal mucosa is the second most common site. It occurs more often in older patients with peak prevalence in the seventh decade of life. A definitive female predominance has been reported. According to the latest English published literature, 531 cases of CA have been reported. We present a case of CA of the hard palate that presented in a 29-year-old female patient. The histopathological and immunohistochemical findings showed typical features of CA and intense expression of pan-cytokeratin and S-100 protein. We also review its differential diagnosis from other salivary gland tumors.

Keywords: Adenoma; canalicular; minor salivary gland; palate.

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Conflict of interest statement

The authors of this manuscript declare that they have no conflicts of interest, real or perceived, financial or nonfinancial in this article.

Figures

Figure 1
Figure 1
Parallel rows of epithelial cells with basophilic nuclei appeared to form ductal structures (H and E, ×40).
Figure 2
Figure 2
Single or bilayered cords of uniform cuboidal epithelial cells which enclose ductal structures in the form of long canals (H and E, ×100).
Figure 3
Figure 3
(a and b) Intense expression of pan-cytokeratin by tumor cells. The staining was cytoplasmic (×40 and × 100). (c and d) Canalicular adenoma stained with S-100 protein. Staining was localized to outer portions of canals (×40 and × 100).
Figure 4
Figure 4
Clinical view about 6 months later with no report of recurrence or any evidence of new lesion.
See this image and copyright information in PMC

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