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Review
. 2021 Aug 16;27(46):11773-11794.
doi: 10.1002/chem.202101232. Epub 2021 Jul 5.

Practical Enzymatic Production of Carbocycles

Weijin Wang  1 , Douglass F Taber  1 , Hans Renata  2
Affiliations
Review

Practical Enzymatic Production of Carbocycles

Weijin Wang et al. Chemistry. .

Abstract

The Pd-catalyzed carbon-carbon bond formation pioneered by Heck in 1969 has dominated medicinal chemistry development for the ensuing fifty years. As the demand for more complex three-dimensional active pharmaceuticals continues to increase, preparative enzyme-mediated assembly, by virtue of its exquisite selectivity and sustainable nature, is poised to provide a practical and affordable alternative for accessing such compounds. In this minireview, we summarize recent state-of-the-art developments in practical enzyme-mediated assembly of carbocycles. When appropriate, background information on the enzymatic transformation is provided and challenges and/or limitations are also highlighted.

Keywords: alicyclic synthesis; biocatalysis; carbocycles; enzymatic methods; medicinal chemistry.

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References

    1. For a detailed discussion of pharma space, see: O. O. Grygorenko, D. M. Volochnyuk, S. V. Ryabukhin, D. B. Judd, Chem. Eur. J. 2020, 26, 1196-1237.
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