Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jun 9;6(1):226.
doi: 10.1038/s41392-021-00644-x.

Fast-spreading SARS-CoV-2 variants: challenges to and new design strategies of COVID-19 vaccines

Weilin Zhou  1 , Wei Wang  2
Affiliations
Review

Fast-spreading SARS-CoV-2 variants: challenges to and new design strategies of COVID-19 vaccines

Weilin Zhou et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
The information of fast-spreading SARS-CoV-2 variants. a Detailed amino acid mutations of SARS-CoV-2 variants (B.1.1.7, B.1.351, B.1.1.28.1) and key mutations are marked in red. b The major structure of SARS-CoV-2, including spike protein, membrane protein, envelope protein, nucleocapsid protein and RNA. As a transmembrane protein, angiotensin-converting enzyme 2 (ACE2) serves as the main entry point into cells for SARS-CoV-2
See this image and copyright information in PMC

References

    1. Sempowski GD, et al. Pandemic preparedness: developing vaccines and therapeutic antibodies for COVID-19. Cell. 2020;181:1458–1463. doi: 10.1016/j.cell.2020.05.041. - DOI - PMC - PubMed
    1. Krammer F. SARS-CoV-2 vaccines in development. Nature. 2020;586:516–527. doi: 10.1038/s41586-020-2798-3. - DOI - PubMed
    1. Callaway E. Fast-spreading COVID variant can elude immune responses. Nature. 2021;589:500–501. doi: 10.1038/d41586-021-00121-z. - DOI - PubMed
    1. Domingo E, Holland JJ. RNA virus mutations and fitness for survival. Annu Rev. Microbiol. 1997;51:151–178. doi: 10.1146/annurev.micro.51.1.151. - DOI - PubMed
    1. Korber B, et al. Tracking changes in SARS-CoV-2 spike: evidence that D614G increases infectivity of the COVID-19 virus. Cell. 2020;182:812–827 e819. doi: 10.1016/j.cell.2020.06.043. - DOI - PMC - PubMed

Publication types

Substances