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Review
. 2021 Jun;23(6):587-594.
doi: 10.1038/s41556-021-00697-8. Epub 2021 Jun 9.

Generic nature of the condensed states of proteins

Monika Fuxreiter  1   2 , Michele Vendruscolo  3
Affiliations
Review

Generic nature of the condensed states of proteins

Monika Fuxreiter et al. Nat Cell Biol. 2021 Jun.

Abstract

Proteins undergoing liquid-liquid phase separation are being discovered at an increasing rate. Since at the high concentrations present in the cell most proteins would be expected to form a liquid condensed state, this state should be considered to be a fundamental state of proteins along with the native state and the amyloid state. Here we discuss the generic nature of the liquid-like and solid-like condensed states, and describe a wide variety of biological functions conferred by these condensed states.

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